Kilgore B S, Dickinson L C, Burnett C R, Lee J, Schedewie H K, Elders M J
J Pediatr. 1979 Apr;94(4):542-5. doi: 10.1016/s0022-3476(79)80007-4.
Suppression of growth without significant alterations in hormonal patterns has been demonstrated for the neurostimulant drug pemoline. Comparison of the in vitro effect of pemoline, methylphenidate, and methamphetamine on somatomedin-stimulated sulfate uptake by cartilage showed all three drugs to be inhibitory. Sulfate uptake by cartilage can be directly related to growth and glycosaminoglycan biosynthesis. Assay of two of the enzymes involved in the glycosaminoglycan biosynthetic pathway showed that methamphetamine and methylphenidate caused a marked depression of xylosyl- and galactosyltransferase enzyme activity. These data suggest an interference with cartilage metabolism as one possible mechanism for the growth retardation observed in children on neurostimulant drug therapy.
已证实神经兴奋剂匹莫林可抑制生长，而激素模式无显著改变。比较匹莫林、哌甲酯和甲基苯丙胺对软骨中生长介素刺激的硫酸盐摄取的体外作用，结果显示这三种药物均具有抑制作用。软骨对硫酸盐的摄取可直接与生长及糖胺聚糖生物合成相关。对糖胺聚糖生物合成途径中涉及的两种酶进行检测表明，甲基苯丙胺和哌甲酯可导致木糖基转移酶和半乳糖基转移酶的活性显著降低。这些数据表明，干扰软骨代谢可能是接受神经兴奋剂药物治疗的儿童出现生长迟缓的一种可能机制。
