Guvenc-Bayram Gokcen, Semen Zeynep, Yalcin Murat
Department of Physiology, Faculty of Veterinary Medicine, Dokuz Eylul University, Izmir 35890, Turkey.
Department of Biochemistry, Faculty of Veterinary Medicine, Dokuz Eylul University, Izmir 35890, Turkey.
Animals (Basel). 2024 Oct 3;14(19):2854. doi: 10.3390/ani14192854.
Neutering of dogs, whether male or female, provides various benefits such as contraception, population control, and the prevention of reproductive disorders and undesirable sexual behaviors. However, it is also associated with an increased risk of obesity, which may be directly linked to post-neutering hormonal changes. Our study aims to determine the effects of neutering on plasma levels of nesfatin-1, serotonin, dopamine, TSH, and T4-hormones implicated in obesity and metabolic regulation. Fourteen dogs (seven males and seven females), aged between 1 and 3 years, were included in this study. Male dogs underwent orchiectomy and females underwent ovariohysterectomy. Blood samples were collected before surgery and on days 7 and 14 post-operatively to measure the plasma levels of these hormones using ELISA. The results showed a significant decrease in nesfatin-1, serotonin, and T4 levels, along with a significant increase in TSH levels in both male and female dogs post-neutering. While these hormonal changes are likely part of the body's adaptive response to neutering, they may represent a potential mechanism that contributes to the long-term tendency toward obesity in neutered dogs.
对狗进行绝育，无论公母，都有诸多益处，如避孕、控制种群数量以及预防生殖系统疾病和不良性行为。然而，绝育也会增加肥胖风险，这可能与绝育后的激素变化直接相关。我们的研究旨在确定绝育对与肥胖和代谢调节相关的nesfatin-1、血清素、多巴胺、促甲状腺激素（TSH）和甲状腺素（T4）激素血浆水平的影响。本研究纳入了14只年龄在1至3岁之间的狗（7只公狗和7只母狗）。公狗接受睾丸切除术，母狗接受卵巢子宫切除术。在手术前以及术后第7天和第14天采集血样，使用酶联免疫吸附测定法（ELISA）测量这些激素的血浆水平。结果显示，绝育后公狗和母狗的nesfatin-1、血清素和T4水平显著下降，同时TSH水平显著升高。虽然这些激素变化可能是身体对绝育的适应性反应的一部分，但它们可能代表了一种潜在机制，导致绝育狗长期有肥胖倾向。
