Gastroenterology, Hepatology, Nutrition, Diabetology and Hereditary Metabolic Diseases Unit, Children's Hospital, CHU de Toulouse, 31300 Toulouse, France.
IRSD, University of Toulouse, INSERM, INRAE, ENVT, UPS, 31024 Toulouse, France.
Int J Mol Sci. 2021 Oct 19;22(20):11255. doi: 10.3390/ijms222011255.
Inflammatory bowel diseases (IBDs), which include Crohn's disease and ulcerative colitis, are multifactorial diseases that involve in particular a modification of the gut microbiota, known as dysbiosis. The initial sets of metataxonomic and metagenomic data first made it possible to approximate the microbiota profile in IBD. In addition, today the new 'omics' techniques have enabled us to draw up a functional and integrative map of the microbiota. The key concern in IBD is to develop biomarkers that allow us to assess the activity of the disease and predict the complications and progression, while also guiding the therapeutic care so as to develop personalized medicine. In this review, we present all of the latest discoveries on the microbiota provided by "omics" and we outline the benefits of these techniques in developing new diagnostic, prognostic and therapeutic tools.
炎症性肠病(IBD)包括克罗恩病和溃疡性结肠炎,是一种多因素疾病,特别是涉及肠道微生物群的改变,即失调。最初的一系列分类组学和宏基因组学数据首先使我们能够大致了解 IBD 中的微生物组特征。此外,如今的新“组学”技术使我们能够绘制出微生物组的功能和综合图谱。IBD 的关键关注点是开发生物标志物,使我们能够评估疾病的活动并预测并发症和进展,同时指导治疗护理,从而开发个性化药物。在这篇综述中,我们介绍了“组学”提供的关于微生物组的最新发现,并概述了这些技术在开发新的诊断、预后和治疗工具方面的益处。
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