Department of Urology, Afliated Hospital of North Sichuan Medical College, Nanchong, China.
BMC Cancer. 2024 Feb 24;24(1):261. doi: 10.1186/s12885-024-12018-x.
Increasing evidence indicates that gut microbiota are closely related to prostate cancer. This study aims to assess the gut microbiota composition in patients with prostate cancer compared to healthy participants, thereby advancing understanding of gut microbiota's role in prostate cancer.
A systematic search was conducted across PubMed, Web of Science, and Embase databases, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The methodological quality of included studies was evaluated using the Newcastle-Ottawa Scale (NOS), and pertinent data were analyzed. The kappa score assessed interrater agreement.
This study encompassed seven research papers, involving 250 prostate cancer patients and 192 controls. The kappa was 0.93. Meta-analysis results showed that alpha-diversity of gut microbiota in prostate cancer patients was significantly lower than in the control group. In terms of gut microbiota abundance, the ratio of Proteobacteria, Bacteroidia, Clostridia, Bacteroidales, Clostridiales, Prevotellaceae, Lachnospiraceae, Prevotella, Escherichia-Shigella, Faecalibacterium, and Bacteroides was higher in prostate cancer patients. Conversely, the abundance ratio of Actinobacteria, Bacteroidetes, Firmicutes, Selenomonadales, Veillonella, and Megasphaera was higher in the control group.
Our study reveals differences in alpha-diversity and abundance of gut microbiota between patients with prostate cancer and controls, indicating gut microbiota dysbiosis in those with prostate cancer. However, given the limited quality and quantity of selected studies, further research is necessary to validate these findings.
越来越多的证据表明，肠道微生物群与前列腺癌密切相关。本研究旨在评估前列腺癌患者与健康参与者之间的肠道微生物群组成，从而深入了解肠道微生物群在前列腺癌中的作用。
根据系统评价和荟萃分析的首选报告项目（PRISMA）指南，对 PubMed、Web of Science 和 Embase 数据库进行了系统搜索。使用纽卡斯尔-渥太华量表（NOS）评估纳入研究的方法学质量，并分析相关数据。kappa 评分评估了评分者间的一致性。
本研究共纳入了 7 篇研究论文，涉及 250 名前列腺癌患者和 192 名对照。kappa 值为 0.93。荟萃分析结果显示，前列腺癌患者的肠道微生物群α多样性明显低于对照组。就肠道微生物群丰度而言，前列腺癌患者的变形菌门、拟杆菌门、梭菌门、拟杆菌目、梭状芽孢杆菌目、普雷沃氏菌科、毛螺菌科、普雷沃氏菌属、埃希氏-志贺氏菌属、粪杆菌属和拟杆菌属的比例较高。相反，对照组中放线菌门、拟杆菌门、厚壁菌门、链球菌目、韦荣球菌科、巨球形菌属和双歧杆菌属的丰度比例较高。
我们的研究揭示了前列腺癌患者与对照组之间肠道微生物群α多样性和丰度的差异，表明前列腺癌患者存在肠道微生物群失调。然而，鉴于所选研究的质量和数量有限，需要进一步的研究来验证这些发现。
