Maeta Akihiro, Takaoka Yuri, Nakano Atsuko, Hiraguchi Yukiko, Hamada Masaaki, Takemura Yutaka, Kawakami Tomoko, Okafuji Ikuo, Kameda Makoto, Takahashi Kyoko
Department of Food Science and Nutrition, School of Food Science and Nutrition, Mukogawa Women's University, 6-46, Ikebiraki-cho, Nishinomiya 663-8558, Japan.
Department of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center, 3-7-1, Habikino 583-8588, Japan.
Children (Basel). 2021 Oct 15;8(10):919. doi: 10.3390/children8100919.
The coronavirus disease 2019 (COVID-19) pandemic's impact on food allergy treatment such as home-based oral immunotherapy (OIT) is not known. This cross-sectional, questionnaire-based anonymized survey screened 2500 parents of children with allergic diseases and was conducted in the pediatric outpatient clinics of 24 hospitals. Basic clinical data of the children were collected along with the degree of allergy control, parental anxiety about emergency visits, and the risk of COVID-19 in the first state of emergency. A total of 2439 (97.6%) questionnaires were collected, and 1315 parents who were instructed to initiate home-based OIT for their children were enrolled (OIT group). Subjective OIT progress compared to before the COVID-19 pandemic was ascertained as "Full", "Middle", "Low", "Little", and "Stop" in 264 (20.1%), 408 (31.0%), 384 (29.2%), 203 (15.4%), and 56 (4.3%) participants, respectively. Anxiety about emergency visits and the risk of COVID-19 were negatively associated with the subjective OIT progress. In Japan, approximately half of the children continued smoothly the home-based OIT during the COVID-19 pandemic. Parents with high levels of anxiety about the disruption of the medical care system due to COVID-19 and the risk of COVID-19 did not experience a smooth continuation of home-based OIT.
2019年冠状病毒病（COVID-19）大流行对食物过敏治疗（如家庭口服免疫疗法[OIT]）的影响尚不清楚。这项基于问卷的横断面匿名调查对2500名患有过敏性疾病儿童的家长进行了筛查，调查在24家医院的儿科门诊进行。收集了儿童的基本临床数据以及过敏控制程度、家长对急诊就诊的焦虑程度，以及在首次紧急状态下感染COVID-19的风险。共收集到2439份问卷（97.6%），招募了1315名被指示为其子女开始家庭OIT的家长（OIT组）。与COVID-19大流行之前相比，主观OIT进展被确定为“完全”“中等”“低”“少”和“停止”的参与者分别为264名（20.1%）、408名（31.0%）、384名（29.2%）、203名（15.4%）和56名（4.3%）。对急诊就诊的焦虑和感染COVID-19的风险与主观OIT进展呈负相关。在日本，大约一半的儿童在COVID-19大流行期间顺利继续进行家庭OIT。对因COVID-19导致医疗系统中断和感染COVID-19风险高度焦虑的家长，其家庭OIT未能顺利持续进行。
