Chimura T, Morisaki N
Jpn J Antibiot. 1986 Oct;39(10):2721-5.
Cefotiam (CTM) was administered to 37 cases of cesarean section and 29 cases of total abdominal hysterectomy for prophylactic purposes. Group I was given the agent at a total dose of 14 g (postoperatively 4, 4, 2, 2 and 2 g), group II at a total dose of 10 g (postoperatively 2, 2, 2, 2 and 2 g) and group III at a total dose of 10 g (2 g during operation and postoperatively 2, 2, 2 and 2 g). When fever indices between the groups were compared, group III showed the lowest level of fever index regardless the type of operation. When the results of laboratory test (WBC, CRP, ESR) between the groups were compared, no significant differences were observed, but group III tended to show lower values than others. No side effects due to CTM were noted. The above results indicate that the administration of CTM during operation was the most effective for protection against postoperative infections in terms of changes in fever index and laboratory test values.
为预防感染，对37例行剖宫产手术的患者和29例行全腹子宫切除术的患者使用了头孢替安（CTM）。第一组给药总量为14克（术后分别为4克、4克、2克、2克和2克），第二组给药总量为10克（术后均为2克），第三组给药总量为10克（术中2克，术后分别为2克、2克、2克和2克）。比较各组的发热指标时，无论手术类型如何，第三组的发热指标水平最低。比较各组的实验室检查结果（白细胞计数、C反应蛋白、红细胞沉降率）时，未观察到显著差异，但第三组的值往往低于其他组。未发现由CTM引起的副作用。上述结果表明，就发热指标和实验室检查值的变化而言，术中使用CTM对预防术后感染最为有效。
