Tabei T, Ishiura T, Matsuda S, Kashiwakura T, Sakamoto S, Kinoshita K, Takamizawa H, Naitou M, Nago R, Ouchi H
Jpn J Antibiot. 1985 Jun;38(6):1703-11.
With the cooperation of 13 medical institutions in the Tokyo area, the methods to determine the prophylactic effect on postoperative infections in gynecological surgery were evaluated. Two hundred and ninety-nine patients were enrolled for the study of postoperative infections, febrile morbidity and fever index following abdominal (275) and vaginal (24) hysterectomies. Prophylactic cefotiam (CTM) of 1 gram was intravenously administered twice a day postoperatively for 3 to 5 days. The rates of postoperative infections were 5.1% (14/275) in abdominal hysterectomy and 4.2% (1/24) in vaginal hysterectomy. The febrile morbidity (57.1% = 8/14) and fever index (52.3 +/- 41.1 degree hours) in the infection group were approximately about 4 times higher than those (12.3% = 32/261, and 15.6 +/- 13.7 degree hours, respectively) in the non-infection group. No significant differences were observed in age, body weight, height of patients, period of operation and blood loss between these 2 groups. These data suggested that febrile morbidity and fever index were able to indicate the prophylactic effect of antibiotics on patients undergoing abdominal and vaginal hysterectomies.
在东京地区13家医疗机构的合作下，对妇科手术术后感染预防效果的判定方法进行了评估。299例患者纳入研究，观察腹部子宫切除术（275例）和阴道子宫切除术（24例）后的感染情况、发热发病率及发热指数。术后预防性静脉注射头孢替安（CTM）1克，每日2次，共3至5天。腹部子宫切除术的术后感染率为5.1%（14/275），阴道子宫切除术为4.2%（1/24）。感染组的发热发病率（57.1% = 8/14）和发热指数（52.3±41.1度小时）约为非感染组（分别为12.3% = 32/261和15.6±13.7度小时）的4倍。两组患者在年龄、体重、身高、手术时间和失血量方面均未观察到显著差异。这些数据表明，发热发病率和发热指数能够表明抗生素对接受腹部和阴道子宫切除术患者的预防效果。
