免疫细胞多样性和异质性在角膜移植存活中的作用：一项系统评价和荟萃分析
Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis.
作者信息
Zhu Jun, Inomata Takenori, Di Zazzo Antonio, Kitazawa Koji, Okumura Yuichi, Coassin Marco, Surico Pier Luigi, Fujio Kenta, Yanagawa Ai, Miura Maria, Akasaki Yasutsugu, Fujimoto Keiichi, Nagino Ken, Midorikawa-Inomata Akie, Hirosawa Kunihiko, Kuwahara Mizu, Huang Tianxiang, Shokirova Hurramhon, Eguchi Atsuko, Murakami Akira
机构信息
Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo 1130033, Japan.
Department of Ophthalmology, Subei People's Hospital of Jiangsu Province, Yangzhou 225001, China.
出版信息
J Clin Med. 2021 Oct 12;10(20):4667. doi: 10.3390/jcm10204667.
Corneal transplantation is one of the most successful forms of solid organ transplantation; however, immune rejection is still a major cause of corneal graft failure. Both innate and adaptive immunity play a significant role in allograft tolerance. Therefore, immune cells, cytokines, and signal-transduction pathways are critical therapeutic targets. In this analysis, we aimed to review the current literature on various immunotherapeutic approaches for corneal-allograft rejection using the PubMed, EMBASE, Web of Science, Cochrane, and China National Knowledge Infrastructure. Retrievable data for meta-analysis were screened and assessed. The review, which evaluated multiple immunotherapeutic approaches to prevent corneal allograft rejection, showed extensive involvement of innate and adaptive immunity components. Understanding the contribution of this immune diversity to the ocular surface is critical for ensuring corneal allograft survival.
角膜移植是实体器官移植中最成功的形式之一；然而，免疫排斥仍然是角膜移植失败的主要原因。固有免疫和适应性免疫在同种异体移植耐受中均发挥重要作用。因此，免疫细胞、细胞因子和信号转导通路是关键的治疗靶点。在本分析中，我们旨在使用PubMed、EMBASE、Web of Science、Cochrane和中国知网，综述目前关于角膜移植排斥反应各种免疫治疗方法的文献。对可检索到的用于荟萃分析的数据进行筛选和评估。该综述评估了多种预防角膜移植排斥反应的免疫治疗方法，显示固有免疫和适应性免疫成分广泛参与其中。了解这种免疫多样性对眼表的作用对于确保角膜移植存活至关重要。
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