Benshabat Dvir, Factor Shai, Maman Eran, Khoury Amal, Krespi Raphael, Ashkenazi Itay, Chechik Ofir, Dolkart Oleg
Division of Orthopedic Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv University Sackler Faculty of Medicine, Weizmann St 6, Tel Aviv 6423906, Israel.
J Clin Med. 2021 Oct 16;10(20):4749. doi: 10.3390/jcm10204749.
Bone marrow aspirate concentrate (BMAC) is an autologous cell composition that is obtained through a needle aspiration from the iliac crest. The purpose of this study was to evaluate the outcomes of patients treated with open reduction and internal fixation with BMAC supplementation for clavicle fracture nonunion. This was a retrospective case series of 21 consecutive patients with clavicle fracture nonunion that were treated with ORIF and BMAC supplementation between 2013 and 2020. Patients were evaluated for fracture union, time to union, complications related to surgical and donor site, and functional outcome using the Quick Disability of the Arm Shoulder and Hand (QDASH), subjective shoulder value (SSV), and pain. The mean age was 41.8 years. The mean follow-up was 36 months. Twenty (95.2%) patients demonstrated fracture union, with a mean time to union of 4.5 months. Good functional scores were achieved: SSV, 74.3; QDASH, 23.3; pain level, 3.1. There were no complications or pain related to the iliac crest donor site. Supplementary BMAC to ORIF in the treatment of clavicle fracture nonunion is a safe method, resulting in high rates of fracture union and good functional outcomes with minimal complications and pain.
骨髓抽吸浓缩物（BMAC）是一种通过从髂嵴进行针吸获得的自体细胞成分。本研究的目的是评估切开复位内固定并补充BMAC治疗锁骨骨折不愈合患者的疗效。这是一项回顾性病例系列研究，纳入了2013年至2020年间连续21例接受切开复位内固定并补充BMAC治疗的锁骨骨折不愈合患者。使用手臂、肩部和手部快速残疾评定量表（QDASH）、主观肩关节评分（SSV）和疼痛评估患者的骨折愈合情况、愈合时间、与手术及供区相关的并发症以及功能结局。平均年龄为41.8岁。平均随访时间为36个月。20例（95.2%）患者实现骨折愈合，平均愈合时间为4.5个月。获得了良好的功能评分：SSV为74.3；QDASH为23.3；疼痛程度为3.1。髂嵴供区未出现并发症或疼痛。切开复位内固定联合补充BMAC治疗锁骨骨折不愈合是一种安全的方法，骨折愈合率高，功能结局良好，并发症和疼痛极少。
