Keeren Kathrin, Böttcher Sindy, Diedrich Sabine
Secretary of the National Commission for Polio Eradication in Germany, Robert Koch Institute, 13353 Berlin, Germany.
National Reference Centre for Poliomyelitis and Enteroviruses, Robert Koch Institute, 13353 Berlin, Germany.
Microorganisms. 2021 Sep 22;9(10):2005. doi: 10.3390/microorganisms9102005.
The major aim of the enterovirus surveillance (EVSurv) in Germany is to prove the absence of poliovirus circulation in the framework of the Global Polio Eradication Program (GPEI). Therefore, a free-of-charge enterovirus diagnostic is offered to all hospitals for patients with symptoms compatible with a polio infection. Within the quality proven laboratory network for enterovirus diagnostic (LaNED), stool and cerebrospinal fluid (CSF) samples from patients with suspected aseptic meningitis/encephalitis or acute flaccid paralysis (AFP) are screened for enterovirus (EV), typing is performed in all EV positive sample to exclude poliovirus infections. Since 2006, ≈200 hospitals from all 16 German federal states have participated annually. On average, 2500 samples (70% stool, 28% CSF) were tested every year. Overall, the majority of the patients studied are children <15 years. During the 15-year period, 53 different EV serotypes were detected. While EV-A71 was most frequently detected in infants, E30 dominated in older children and adults. Polioviruses were not detected. The German enterovirus surveillance allows monitoring of the circulation of clinically relevant serotypes resulting in continuous data about non-polio enterovirus epidemiology.
德国肠道病毒监测（EVSurv）的主要目的是在全球根除脊髓灰质炎计划（GPEI）框架内证明脊髓灰质炎病毒没有传播。因此，向所有医院为出现与脊髓灰质炎感染相符症状的患者提供免费的肠道病毒诊断。在经质量验证的肠道病毒诊断实验室网络（LaNED）内，对疑似无菌性脑膜炎/脑炎或急性弛缓性麻痹（AFP）患者的粪便和脑脊液（CSF）样本进行肠道病毒（EV）筛查，对所有EV阳性样本进行分型以排除脊髓灰质炎病毒感染。自2006年以来，德国16个联邦州的约200家医院每年都参与。每年平均检测2500份样本（70%为粪便，28%为脑脊液）。总体而言，研究的大多数患者为15岁以下儿童。在这15年期间，检测到53种不同的EV血清型。虽然EV-A71在婴儿中最常被检测到，但E30在大龄儿童和成人中占主导地位。未检测到脊髓灰质炎病毒。德国肠道病毒监测有助于监测临床相关血清型传播情况，从而持续获取非脊髓灰质炎肠道病毒流行病学数据。
