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葡萄牙的输入性疟疾:抗疟药物耐药基因中的多态性患病率及…… (原文结尾不完整)

Imported Malaria in Portugal: Prevalence of Polymorphisms in the Anti-Malarial Drug Resistance Genes and .

作者信息

Serrano Debora, Santos-Reis Ana, Silva Clemente, Dias Ana, Dias Brigite, Toscano Cristina, Conceição Cláudia, Baptista-Fernandes Teresa, Nogueira Fatima

机构信息

Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa (IHMT-NOVA), Rua da Junqueira 100, 1349-008 Lisboa, Portugal.

Laboratório de Microbiologia Clínica e Biologia Molecular, Serviço de Patologia Clínica, Centro Hospitalar Lisboa Ocidental (CHLO), Rua da Junqueira 126, 1349-019 Lisboa, Portugal.

出版信息

Microorganisms. 2021 Sep 28;9(10):2045. doi: 10.3390/microorganisms9102045.

Abstract

Malaria is one of the 'big three' killer infectious diseases, alongside tuberculosis and HIV. In non-endemic areas, malaria may occur in travelers who have recently been to or visited endemic regions. The number of imported malaria cases in Portugal has increased in recent years, mostly due to the close relationship with the community of Portuguese language countries. Samples were collected from malaria-infected patients attending Centro Hospitalar Lisboa Ocidental (CHLO) or the outpatient clinic of Instituto de Higiene e Medicina Tropical (IHMT-NOVA) between March 2014 and May 2021. Molecular characterization of and genes was performed. We analyzed 232 imported malaria cases. The majority (68.53%) of the patients came from Angola and only three patients travelled to a non-African country; one to Brazil and two to Indonesia. was diagnosed in 81.47% of the cases, in 7.33%, 6.47% and 1.72% carried . No mutations were detected in . Regarding , the wild-type haplotype (N86/Y184/D1246) was also the most prevalent (64.71%) and N86/184F/D1246 was detected in 26.47% of the cases. The typical imported malaria case was middle-aged male, traveling from Angola, infected with carrying wild type and . Our study highlights the need for constant surveillance of malaria parasites imported into Portugal as an important pillar of public health.

摘要

疟疾是与结核病和艾滋病并列的“三大”致命传染病之一。在非流行地区,疟疾可能发生在近期去过或到访过流行地区的旅行者身上。近年来,葡萄牙输入性疟疾病例数量有所增加,这主要归因于其与葡语国家社区的密切关系。2014年3月至2021年5月期间,从前往里斯本西部中心医院(CHLO)或热带卫生与医学研究所(IHMT-NOVA)门诊就诊的疟疾感染患者中采集样本。对 和 基因进行了分子特征分析。我们分析了232例输入性疟疾病例。大多数患者(68.53%)来自安哥拉,只有三名患者前往了非洲以外的国家;一名前往巴西,两名前往印度尼西亚。81.47%的病例被诊断为 ,7.33%为 ,6.47%的 和1.72%的 携带 。 未检测到突变。关于 ,野生型单倍型(N86/Y184/D1246)也是最常见的(64.71%),26.47%的病例检测到N86/184F/D1246。典型的输入性疟疾病例是中年男性,从安哥拉旅行而来,感染了携带野生型 和 的 。我们的研究强调,持续监测输入葡萄牙的疟原虫作为公共卫生的重要支柱的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a32c/8538333/784b59b7ad34/microorganisms-09-02045-g001.jpg

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