The In Vitro Potential of 1-(1-indol-3-yl) Derivatives against spp. and as Tyrosinase Inhibitors.

Given the increased antimicrobial resistance, global effort is currently focused on the identification of novel compounds, both of natural and chemical origin. The present study reports on the antifungal potential of 1-(1-indol-3-yl) derivatives, previously known as tyrosinase inhibitors. The effect of seven compounds (indicated as -) was determined against ATCC 10531, three clinical isolates of , two clinical isolates of , two clinical isolates of and ATCC 16404. The effect of these derivatives on tyrosinase enzymatic activity was also evaluated. Results showed a fungicidal activity of compounds , and against all tested strains at concentrations ranging between 0.250 and 1 mg/mL. Furthermore, the association between and fluconazole and between and caspofungin showed a trend of indifference tending toward synergism. Compound was also able to inhibit microbial tyrosinase up to ~28% at the concentration of 0.250 mg/mL. These data could help provide novel therapeutics for topical use to treat fungal infections and increase the potential effectiveness of the association between novel compounds and commercial antifungals in order to combat drug resistance.