Yokoyama Takashi, Nishimura Tomoyasu, Uwamino Yoshifumi, Kosaki Kenjiro, Furusaki Koichi, Onishi Rumiko, Onodera Takashi, Haritani Makoto, Sugiura Katsuaki, Kirisawa Rikio, Hasegawa Naoki
Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Department of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan.
Microorganisms. 2021 Oct 4;9(10):2096. doi: 10.3390/microorganisms9102096.
Here, the virucidal effect of calcium bicarbonate with a mesoscopic structure (CAC-717) on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was determined. Assays showed that CAC-717 had a strong virucidal effect on all examined SARS-CoV-2 isolates, including variant strains. The viral infectivity decreased within 15 s, and the virucidal activity of CAC-717 at a 1:49 ratio was similar to that of ethanol disinfectant. CAC-717 neutralization eliminated this virucidal effect, indicating that the alkaline condition of CAC-717 is important for virus inactivation and is an indicator of its mesoscopic structure and virucidal activity. The virucidal effect was observed in the presence of organic matter (bovine serum albumin). CAC-717 is a non-invasive and non-flammable substance with a low environmental burden, and its usefulness as a novel disinfectant has been confirmed.
在此,测定了具有介观结构的碳酸氢钙(CAC-717)对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的杀病毒效果。试验表明,CAC-717对所有检测的SARS-CoV-2分离株,包括变异株,均有很强的杀病毒作用。病毒感染性在15秒内降低,且CAC-717以1:49比例时的杀病毒活性与乙醇消毒剂相似。CAC-717中和作用消除了这种杀病毒效果,表明CAC-717的碱性条件对病毒灭活很重要,且是其介观结构和杀病毒活性的一个指标。在存在有机物(牛血清白蛋白)的情况下观察到了杀病毒效果。CAC-717是一种非侵入性、不可燃且环境负担低的物质,其作为新型消毒剂的效用已得到证实。