Sakudo Akikazu, Furusaki Koichi, Onishi Rumiko, Onodera Takashi, Yoshikawa Yasuhiro
School of Veterinary Medicine, Okayama University of Science, Imabari 794-8555, Ehime, Japan.
Mineral Activation Technical Research Center, Omuta 836-0041, Fukuoka, Japan.
Microorganisms. 2025 Feb 25;13(3):507. doi: 10.3390/microorganisms13030507.
Recent studies on utilizing biological functions of natural substances that mimic the mesoscopic structures (nanoparticles of about 50 to 500 nm) found in plant growth points and coral skeletons have been reported. After the calcium hydrogen carbonate contained in materials derived from plants and coral are separated, the crystals of the mesoscopic structure can be reformed by applying a high voltage under a specific set of conditions. A suspension of these mesoscopic crystals in water (CAC-717) can be used as an effective disinfectant. CAC-717 exhibits universal virucidal activity against both enveloped and non-enveloped viruses as well as bactericidal and anti-prion activity. Moreover, in comparison to sodium hypochlorite, the potency of CAC-717 as a disinfectant is less susceptible to organic substances such as albumin. The disinfection activity of CAC-717 is maintained for at least 6 years and 4 months after storage at room temperature. CAC-717 is non-irritating and harmless to humans and animals, making it a promising biosafe disinfectant. This review explores the disinfection activity of CAC-717 as well as the potential and future uses of this material.
最近有报道称,对利用天然物质的生物学功能进行了研究,这些天然物质可模拟在植物生长点和珊瑚骨骼中发现的介观结构(约50至500纳米的纳米颗粒)。在分离出植物和珊瑚衍生材料中所含的碳酸氢钙后,通过在特定条件下施加高压,可以使介观结构的晶体重新形成。这些介观晶体在水中的悬浮液(CAC - 717)可用作有效的消毒剂。CAC - 717对包膜病毒和非包膜病毒均表现出普遍的杀病毒活性,以及杀菌和抗朊病毒活性。此外,与次氯酸钠相比,CAC - 717作为消毒剂的效力受白蛋白等有机物质的影响较小。CAC - 717在室温下储存至少6年零4个月后仍保持消毒活性。CAC - 717对人类和动物无刺激且无害,使其成为一种有前景的生物安全消毒剂。本综述探讨了CAC - 717的消毒活性以及该材料的潜在用途和未来应用。