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骨组织支架材料的设计

Design of Materials for Bone Tissue Scaffolds.

作者信息

Boccaccio Antonio

机构信息

Dipartimento di Meccanica, Matematica e Management, Politecnico di Bari, 70125 Bari, Italy.

出版信息

Materials (Basel). 2021 Oct 12;14(20):5985. doi: 10.3390/ma14205985.

DOI:10.3390/ma14205985
PMID:34683577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8541387/
Abstract

The strong impulse recently experienced by the manufacturing technologies as well as the development of innovative biocompatible materials has allowed the fabrication of high-performing scaffolds for bone tissue engineering. The design process of materials for bone tissue scaffolds represents, nowadays, an issue of crucial importance and the object of study of many researchers throughout the world. A number of studies have been conducted, aimed at identifying the optimal material, geometry, and surface that the scaffold must possess to stimulate the formation of the largest amounts of bone in the shortest time possible. This book presents a collection of 10 research articles and 2 review papers describing numerical and experimental design techniques definitively aimed at improving the scaffold performance, shortening the healing time, and increasing the success rate of the scaffold implantation process.

摘要

制造技术最近经历的强大推动力以及创新生物相容性材料的发展,使得用于骨组织工程的高性能支架的制造成为可能。如今,骨组织支架材料的设计过程是一个至关重要的问题,也是全世界许多研究人员的研究对象。已经进行了大量研究,旨在确定支架必须具备的最佳材料、几何形状和表面,以便在尽可能短的时间内刺激形成最大量的骨。本书呈现了10篇研究文章和2篇综述论文的合集,描述了明确旨在提高支架性能、缩短愈合时间并提高支架植入过程成功率的数值和实验设计技术。

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1
Design of Materials for Bone Tissue Scaffolds.骨组织支架材料的设计
Materials (Basel). 2021 Oct 12;14(20):5985. doi: 10.3390/ma14205985.
2
Current state of fabrication technologies and materials for bone tissue engineering.骨组织工程的制造技术和材料的现状。
Acta Biomater. 2018 Oct 15;80:1-30. doi: 10.1016/j.actbio.2018.09.031. Epub 2018 Sep 22.
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Three-dimensional (3D) printed scaffold and material selection for bone repair.三维(3D)打印支架和用于骨修复的材料选择。
Acta Biomater. 2019 Jan 15;84:16-33. doi: 10.1016/j.actbio.2018.11.039. Epub 2018 Nov 24.
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Geometry Design Optimization of Functionally Graded Scaffolds for Bone Tissue Engineering: A Mechanobiological Approach.用于骨组织工程的功能梯度支架的几何设计优化:一种力学生物学方法。
PLoS One. 2016 Jan 15;11(1):e0146935. doi: 10.1371/journal.pone.0146935. eCollection 2016.
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Bone tissue regeneration: the role of scaffold geometry.骨组织再生:支架几何形状的作用。
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Int J Med Sci. 2018 Jan 1;15(1):16-22. doi: 10.7150/ijms.20522. eCollection 2018.
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Metal Material, Properties and Design Methods of Porous Biomedical Scaffolds for Additive Manufacturing: A Review.用于增材制造的多孔生物医学支架的金属材料、性能及设计方法:综述
Front Bioeng Biotechnol. 2021 Mar 26;9:641130. doi: 10.3389/fbioe.2021.641130. eCollection 2021.
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A comparative study of shear stresses in collagen-glycosaminoglycan and calcium phosphate scaffolds in bone tissue-engineering bioreactors.骨组织工程生物反应器中胶原蛋白-糖胺聚糖和磷酸钙支架剪切应力的比较研究。
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Scaffold Pore Geometry Guides Gene Regulation and Bone-like Tissue Formation in Dynamic Cultures.支架孔几何结构指导动态培养中的基因调控和类骨组织形成。
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Materials (Basel). 2021 Jul 3;14(13):3735. doi: 10.3390/ma14133735.
2
Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies.新型骨再生疗法开发中的骨形态发生蛋白、载体及动物模型
Materials (Basel). 2021 Jun 24;14(13):3513. doi: 10.3390/ma14133513.
3
Irregular Load Adapted Scaffold Optimization: A Computational Framework Based on Mechanobiological Criteria.不规则载荷适应性支架优化:基于力学生物学标准的计算框架
ACS Biomater Sci Eng. 2019 Oct 14;5(10):5392-5411. doi: 10.1021/acsbiomaterials.9b01023. Epub 2019 Sep 6.
4
Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review.通过设计质量探索增材制造用于骨再生的钛超材料的大孔隙率:一项系统文献综述
Materials (Basel). 2020 Oct 27;13(21):4794. doi: 10.3390/ma13214794.
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In Situ and Ex Situ Designed Hydroxyapatite: Bacterial Cellulose Materials with Biomedical Applications.原位和非原位设计的羟基磷灰石:具有生物医学应用的细菌纤维素材料。
Materials (Basel). 2020 Oct 27;13(21):4793. doi: 10.3390/ma13214793.
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Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes.在寡聚芪存在的情况下用3D打印支架对骨组织进行生物工程构建
Materials (Basel). 2020 Oct 9;13(20):4471. doi: 10.3390/ma13204471.
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Materials (Basel). 2020 Sep 13;13(18):4062. doi: 10.3390/ma13184062.
8
Enhanced Osteogenic Differentiation of Human Primary Mesenchymal Stem and Progenitor Cultures on Graphene Oxide/Poly(methyl methacrylate) Composite Scaffolds.人原代间充质干细胞和祖细胞在氧化石墨烯/聚甲基丙烯酸甲酯复合支架上的成骨分化增强
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