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骨组织支架材料的设计

Design of Materials for Bone Tissue Scaffolds.

作者信息

Boccaccio Antonio

机构信息

Dipartimento di Meccanica, Matematica e Management, Politecnico di Bari, 70125 Bari, Italy.

出版信息

Materials (Basel). 2021 Oct 12;14(20):5985. doi: 10.3390/ma14205985.

Abstract

The strong impulse recently experienced by the manufacturing technologies as well as the development of innovative biocompatible materials has allowed the fabrication of high-performing scaffolds for bone tissue engineering. The design process of materials for bone tissue scaffolds represents, nowadays, an issue of crucial importance and the object of study of many researchers throughout the world. A number of studies have been conducted, aimed at identifying the optimal material, geometry, and surface that the scaffold must possess to stimulate the formation of the largest amounts of bone in the shortest time possible. This book presents a collection of 10 research articles and 2 review papers describing numerical and experimental design techniques definitively aimed at improving the scaffold performance, shortening the healing time, and increasing the success rate of the scaffold implantation process.

摘要

制造技术最近经历的强大推动力以及创新生物相容性材料的发展,使得用于骨组织工程的高性能支架的制造成为可能。如今,骨组织支架材料的设计过程是一个至关重要的问题,也是全世界许多研究人员的研究对象。已经进行了大量研究,旨在确定支架必须具备的最佳材料、几何形状和表面,以便在尽可能短的时间内刺激形成最大量的骨。本书呈现了10篇研究文章和2篇综述论文的合集,描述了明确旨在提高支架性能、缩短愈合时间并提高支架植入过程成功率的数值和实验设计技术。

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本文引用的文献

1
Titanium Functionalized with Polylysine Homopolymers: In Vitro Enhancement of Cells Growth.
Materials (Basel). 2021 Jul 3;14(13):3735. doi: 10.3390/ma14133735.
3
Irregular Load Adapted Scaffold Optimization: A Computational Framework Based on Mechanobiological Criteria.
ACS Biomater Sci Eng. 2019 Oct 14;5(10):5392-5411. doi: 10.1021/acsbiomaterials.9b01023. Epub 2019 Sep 6.
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Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes.
Materials (Basel). 2020 Oct 9;13(20):4471. doi: 10.3390/ma13204471.
7
An Algorithm to Optimize the Micro-Geometrical Dimensions of Scaffolds with Spherical Pores.
Materials (Basel). 2020 Sep 13;13(18):4062. doi: 10.3390/ma13184062.

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