Posa Francesca, Di Benedetto Adriana, Ravagnan Giampietro, Cavalcanti-Adam Elisabetta Ada, Lo Muzio Lorenzo, Percoco Gianluca, Mori Giorgio
Department of Clinical and Experimental Medicine, University of Foggia, viale Pinto 1, 71122 Foggia, Italy.
Department of Biophysical Chemistry, Heidelberg University and Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, Germany.
Materials (Basel). 2020 Oct 9;13(20):4471. doi: 10.3390/ma13204471.
Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniques, interesting results, in filling of bone lesions and dehiscence have been obtained using adult mesenchymal stem cells (MSCs) integrated with biocompatible scaffolds. The geometry of the scaffold has critical effects on cell adhesion, proliferation and differentiation. Many cytokines and compounds have been demonstrated to be effective in promoting MSCs osteogenic differentiation. Oligostilbenes, such as Resveratrol (Res) and Polydatin (Pol), can increase MSCs osteoblastic features. 3D printing is an excellent technique to create scaffolds customized for the lesion and thus optimized for the patient. In this work we analyze osteoblastic features of adult MSCs integrated with 3D-printed polycarbonate scaffolds differentiated in the presence of oligostilbenes.
决定骨组织流失的疾病对任何年龄段的人都有很大影响。基于组织工程的治疗方法可以改善骨愈合。科学研究表明，在骨再生技术中，使用与生物相容性支架整合的成人间充质干细胞（MSCs）在填充骨病变和骨裂开方面取得了有趣的结果。支架的几何形状对细胞粘附、增殖和分化有关键影响。许多细胞因子和化合物已被证明可有效促进MSCs的成骨分化。寡聚芪类化合物，如白藜芦醇（Res）和虎杖苷（Pol），可增加MSCs的成骨细胞特征。3D打印是一种出色的技术，可创建针对病变定制并因此为患者优化的支架。在这项工作中，我们分析了与在寡聚芪类化合物存在下分化的3D打印聚碳酸酯支架整合的成人MSCs的成骨细胞特征。
