Structure and Cytotoxicity of Novel Lignans and Lignan Glycosides from the Aerial Parts of .

Previously, the authors conducted phytochemical investigations of the aerial parts of and reported triterpene glycosides and lignan derivatives. In continuation of the preceding studies, 17 lignans and lignan glycosides (-) were isolated, including seven new compounds (-). Herein, the structure of the new compounds was determined based on spectroscopic analysis and enzymatic hydrolysis. The cytotoxicity of - against HL-60 human promyelocytic leukemia cells was examined. Compounds - and - were cytotoxic to HL-60 cells, with IC values in the range of 2.7-17 μM. Compound , which was the most cytotoxic among the unprecedented compounds, was shown to induce apoptotic cell death in HL-60 cells.