Kincses Dóra, Böddi Katalin, Őri Zsuzsanna, Lovász Bálint Viktor, Jeges Sára, Szalma József, Kunsági-Máté Sándor, Lempel Edina
Department of Restorative Dentistry and Periodontology, University of Pécs Medical School, Dischka Gy. Street 5, 7621 Pécs, Hungary.
Department of Biochemistry and Medical Chemistry, University of Pécs Medical School, Szigeti Street 12, 7624 Pécs, Hungary.
Polymers (Basel). 2021 Oct 19;13(20):3599. doi: 10.3390/polym13203599.
Detection of unreacted monomers from pre-heated resin-based dental composites (RBC) is not a well-investigated topic so far. The objectives were to determine the temperature changes during the application and polymerization, the degree of conversion (DC) and unreacted monomer elution of room temperature (RT), and pre-heated thermoviscous [VisCalor Bulk(VCB)] and high-viscosity full-body contemporary [Filtek One Bulk(FOB)] bulk-fill RBCs. The RBCs' temperatures during the sample preparation were recorded with a K-type thermocouple. The DC at the top and bottom was measured with micro-Raman spectroscopy and the amounts of eluted BisGMA, UDMA, DDMA, and TEGDMA were assessed with High-Performance Liquid Chromatography. The temperatures of the pre-heated RBCs decreased rapidly during the manipulation phase. The temperature rise during photopolymerization reflects the bottom DCs. The differences in DC% between the top and the bottom were significant. RT VCB had a lower DC% compared to FOB. Pre-heating did not influence the DC, except on the bottom surface of FOB where a significant decrease was measured. Pre-heating significantly decreased the elution of BisGMA, UDMA, DDMA in the case of FOB, meanwhile, it had no effect on monomer release from VCB, except TEGDMA, which elution was decreased. In comparison, RBC composition had a stronger influence on DC and monomer elution, than pre-cure temperature.
到目前为止，检测预热后的树脂基牙科复合材料（RBC）中未反应的单体这一课题尚未得到充分研究。研究目的是确定室温（RT）、预热热粘性[VisCalor Bulk（VCB）]和高粘性全身当代型[Filtek One Bulk（FOB）]大体积填充RBC在应用和聚合过程中的温度变化、转化率（DC）以及未反应单体的洗脱情况。在样品制备过程中，用K型热电偶记录RBC的温度。用显微拉曼光谱法测量顶部和底部的DC，并用高效液相色谱法评估洗脱的双酚A缩水甘油醚甲基丙烯酸酯（BisGMA）、二甲基丙烯酸氨基甲酸酯（UDMA）、二甲基丙烯酸二缩乙二醇酯（DDMA）和三乙二醇二甲基丙烯酸酯（TEGDMA）的量。预热后的RBC在操作阶段温度迅速下降。光聚合过程中的温度上升反映了底部的DC。顶部和底部之间的DC%差异显著。与FOB相比，RT VCB的DC%较低。除了在FOB的底部表面测量到显著下降外，预热对DC没有影响。对于FOB，预热显著降低了BisGMA、UDMA、DDMA的洗脱，同时，除了TEGDMA洗脱减少外，对VCB的单体释放没有影响。相比之下，RBC组成对DC和单体洗脱的影响比预固化温度更强。
