Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.
Cells. 2021 Oct 1;10(10):2624. doi: 10.3390/cells10102624.
Changes in nuclear shape have been extensively associated with the dynamics and functionality of cancer cells. In most normal cells, nuclei have a regular ellipsoid shape and minimal variation in nuclear size; however, an irregular nuclear contour and abnormal nuclear size is often observed in cancer, including pancreatic cancer. Furthermore, alterations in nuclear morphology have become the 'gold standard' for tumor staging and grading. Beyond the utility of altered nuclear morphology as a diagnostic tool in cancer, the implications of altered nuclear structure for the biology and behavior of cancer cells are profound as changes in nuclear morphology could impact cellular responses to physical strain, adaptation during migration, chromatin organization, and gene expression. Here, we aim to highlight and discuss the factors that regulate nuclear dynamics and their implications for pancreatic cancer biology.
核形状的变化与癌细胞的动力学和功能密切相关。在大多数正常细胞中，核呈规则的椭圆形，核大小的变化很小；然而，在癌症中，包括胰腺癌，经常观察到核轮廓不规则和核大小异常。此外，核形态的改变已成为肿瘤分期和分级的“金标准”。除了改变的核形态作为癌症诊断工具的实用性之外，核结构的改变对癌细胞的生物学和行为的影响也是深远的，因为核形态的改变可能会影响细胞对物理应变的反应、迁移过程中的适应、染色质组织和基因表达。在这里，我们旨在强调和讨论调节核动力学的因素及其对胰腺癌生物学的影响。
