Sri Sankaradeva Nethralaya, 96 Basistha Road, Saurabh Nagar, Beltola Tiniali, Guwahati, Assam, 781028, India.
BMC Ophthalmol. 2021 Oct 22;21(1):374. doi: 10.1186/s12886-021-02138-4.
To study the influence of media opacity due to cataract on the development of axial length in paediatric patients from North-East India, using optical biometry.
This is a prospective, observational study, including consecutive patients attending the paediatric ophthalmology clinic, over a period of 1 year. Patients with other ocular and systemic diseases, unfit for optical biometry measurements due to dense cataract, nystagmus and strabismus were excluded and rest divided into three groups after proper age matching - 1. Group A (Bilateral cataract) 2. Group B (Unilateral cataract) 3. Group C (Bilateral normal). The axial length of the various groups was analysed using independent sample test (for bilateral cataract group) and paired t-test (for unilateral cataract group). Linear regression analysis between age and axial length was done.
A total of 177 patients were included.80 cases in Group A (bilateral cataract), 18 cases in Group B (unilateral cataract) and 79 in Group C (bilateral normal) The mean age of the patients in all the groups was 8.88 ± 3.51 years (range: 1-17 years). The bivariate analysis and simple linear regression revealed a statistically significant correlation between age and AL in case of cataractous eyes. (Pearson's coefficient: 0.341, p < 0.001). The mean AL was significantly longer (p = 0.013) in the cataractous eyes (mean = 23.38 ± 2.08 mm) of Group A(bilateral cataract) in the 7-12 years age group as compared to the bilaterally normal eyes (mean AL = 22.57 ± 0.70 mm) of patients in the same age group in Group C. The mean AL of cataractous eyes in group B (unilateral cataract) (mean = 22.46 ± 1.73 mm) as compared to the fellow normal eyes, (mean = 21.87 ± 0.97 mm) was not statistically significant.
Cataractous eyes have an abnormal axial length development. The influence of media opacity due to cataract on development of axial length in paediatric eyes in the North-East Indian population is variable, in line with global data on the same. Although there is some influence of media opacity, the exact nature is not clearly understood and may have a crucial interaction with genetic and other environmental factors. Genetic testing integrated with biometric analysis is recommended for further understanding of the ocular growth and development.
使用光学生物测量法研究印度东北部儿童白内障引起的介质不透明度对眼轴发育的影响。
这是一项前瞻性、观察性研究，包括在一年期间连续就诊于儿科眼科诊所的患者。患有其他眼部和全身疾病、由于白内障浓密、眼球震颤和斜视而不适合光学生物测量的患者被排除在外，其余患者根据年龄适当分组为三组：1. A 组（双侧白内障）；2. B 组（单侧白内障）；3. C 组（双侧正常）。使用独立样本检验（双侧白内障组）和配对 t 检验（单侧白内障组）分析各组的眼轴长度。进行年龄与眼轴长度之间的线性回归分析。
共纳入 177 例患者。80 例 A 组（双侧白内障），18 例 B 组（单侧白内障），79 例 C 组（双侧正常）。所有组的患者平均年龄为 8.88±3.51 岁（范围：1-17 岁）。双变量分析和简单线性回归显示，白内障眼的年龄与 AL 之间存在统计学显著相关性。（皮尔逊系数：0.341，p<0.001）。7-12 岁年龄组中，A 组（双侧白内障）白内障眼的平均 AL 明显较长（p=0.013），与同一年龄组 C 组双侧正常眼的平均 AL（22.57±0.70mm）相比。B 组（单侧白内障）白内障眼的平均 AL（22.46±1.73mm）与对侧正常眼的平均 AL（21.87±0.97mm）相比无统计学意义。
白内障眼的眼轴发育异常。印度东北部儿童白内障引起的介质不透明度对眼轴发育的影响是可变的，与全球同类数据一致。虽然有一定程度的介质不透明度影响，但确切性质尚不清楚，可能与遗传和其他环境因素有重要相互作用。建议进行遗传检测与生物测量分析相结合，以进一步了解眼球生长发育。
