锰调节异常在神经系统疾病中的作用：新出现的证据
The role of manganese dysregulation in neurological disease: emerging evidence.
作者信息
Budinger Dimitri, Barral Serena, Soo Audrey K S, Kurian Manju A
机构信息
Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, University College London, London, UK.
Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, University College London, London, UK; Department of Neurology, Great Ormond Street Hospital, London, UK.
出版信息
Lancet Neurol. 2021 Nov;20(11):956-968. doi: 10.1016/S1474-4422(21)00238-6.
Manganese is an essential trace metal. The dysregulation of manganese seen in a broad spectrum of neurological disorders reflects its importance in brain development and key neurophysiological processes. Historically, the observation of acquired manganism in miners and people who misuse drugs provided early evidence of brain toxicity related to manganese exposure. The identification of inherited manganese transportopathies, which cause neurodevelopmental and neurodegenerative syndromes, further corroborates the neurotoxic potential of this element. Moreover, manganese dyshomoeostasis is also implicated in Parkinson's disease and other neurodegenerative conditions, such as Alzheimer's disease and Huntington's disease. Ongoing and future research will facilitate the development of better targeted therapeutical strategies than are currently available for manganese-associated neurological disorders.
锰是一种必需的痕量金属。在多种神经疾病中观察到的锰失调反映了其在大脑发育和关键神经生理过程中的重要性。历史上，在矿工和药物滥用者中发现的后天性锰中毒为与锰暴露相关的脑毒性提供了早期证据。遗传性锰转运障碍可导致神经发育和神经退行性综合征，这进一步证实了该元素的神经毒性潜力。此外，锰稳态失调还与帕金森病以及其他神经退行性疾病有关，如阿尔茨海默病和亨廷顿病。正在进行的和未来的研究将有助于开发比目前用于治疗与锰相关的神经疾病的方法更具针对性的治疗策略。
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