Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Chin J Nat Med. 2021 Oct;19(10):796-800. doi: 10.1016/S1875-5364(21)60075-4.
In a continuing search for biological natural products with structure diversity from traditional Chinese herbs, five new sesquineolignans (1-5) were isolated from an ethyl acetate extract of the twigs of Litsea cubeba. Their structures were elucidated based on MS, 1D and 2D NMR spectroscopic data, as well as experimental electronic circular dichroism (ECD) spectra. Compounds 1-5 showed moderate inhibitory effects against LPS-induced NO production in RAW264.7 macrophages, with IC values of 16.2, 20.2, 22.1, 15.1, and 16.6 μmol·L, respectively.
在继续从传统中药中寻找具有结构多样性的生物天然产物的过程中，从山鸡椒的嫩枝乙酸乙酯提取物中分离得到了五个新的倍半萜木脂素（1-5）。根据 MS、1D 和 2D NMR 光谱数据以及实验电子圆二色谱（ECD）光谱，确定了它们的结构。化合物 1-5 对 LPS 诱导的 RAW264.7 巨噬细胞中 NO 生成显示出适度的抑制作用，IC 值分别为 16.2、20.2、22.1、15.1 和 16.6μmol·L。
Zotero 插件