从 Merr. 中分离得到的 3 个新的愈创木烷型倍半萜和 1 个单萜
Three new guaiane-type sesquiterpenoids and a monoterpenoid from Merr.
机构信息
Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Institute of Chinese Medicinal Sciences, Guangdong Pharmaceutical University, Guangzhou, China.
出版信息
Nat Prod Res. 2022 Jul;36(13):3271-3279. doi: 10.1080/14786419.2020.1853727. Epub 2020 Dec 1.
Three undescribed guaiane-type sesquiterpenes (), and a monoterpenoid () along with eleven known compounds () were isolated from the crude extract of Merr. The structures of all the isolated compounds were extensively elucidated on the basis of comprehensive spectroscopic techniques (HRESIMS, 1 D NMR, and 2 D NMR). Their relative and absolute configurations were comprehensively established by NOESY spectroscopy, circular dichroism (ECD) and the calculated ECD analysis. All the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide production. Amongst tested compounds, compounds exhibited moderate inhibitory activities against the production of nitric oxide with IC value of 35.5, 32.1, 46.7 M in RAW264.7 cells stimulated by LPS, respectively.
从 Merr. 的粗提物中分离得到了三种未被描述的愈创木烷型倍半萜（）和一种单萜（），以及 11 种已知化合物（）。基于全面的光谱技术（HRESIMS、1D NMR 和 2D NMR），详细阐明了所有分离化合物的结构。通过 NOESY 光谱、圆二色性（ECD）和计算 ECD 分析全面确定了它们的相对和绝对构型。通过测量一氧化氮产生量，对所有分离物进行抗炎活性测试。在所测试的化合物中，化合物表现出对 LPS 刺激的 RAW264.7 细胞中一氧化氮产生的适度抑制活性，其 IC 值分别为 35.5、32.1 和 46.7 μM。
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