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默认模式网络的历程:发展、功能及其对心理健康的影响

The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health.

作者信息

Azarias Felipe Rici, Almeida Gustavo Henrique Doná Rodrigues, de Melo Luana Félix, Rici Rose Eli Grassi, Maria Durvanei Augusto

机构信息

Graduate Program in Medical Sciences, School of Medicine, University of São Paulo, São Paulo 05508-220, SP, Brazil.

Graduate Program in Anatomy of Domestic and Wild Animals, College of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-220, SP, Brazil.

出版信息

Biology (Basel). 2025 Apr 10;14(4):395. doi: 10.3390/biology14040395.

Abstract

The Default Mode Network has been extensively studied in recent decades due to its central role in higher cognitive processes and its relevance for understanding mental disorders. This neural network, characterized by synchronized and coherent activity at rest, is intrinsically linked to self-reflection, mental exploration, social interaction, and emotional processing. Our understanding of the DMN extends beyond humans to non-human animals, where it has been observed in various species, highlighting its evolutionary basis and adaptive significance throughout phylogenetic history. Additionally, the DMN plays a crucial role in brain development during childhood and adolescence, influencing fundamental cognitive and emotional processes. This literature review aims to provide a comprehensive overview of the DMN, addressing its structural, functional, and evolutionary aspects, as well as its impact from infancy to adulthood. By gaining a deeper understanding of the organization and function of the DMN, we can advance our knowledge of the neural mechanisms that underlie cognition, behavior, and mental health. This, in turn, can lead to more effective therapeutic strategies for a range of neuropsychiatric conditions.

摘要

近几十年来,默认模式网络因其在高级认知过程中的核心作用以及与理解精神障碍的相关性而受到广泛研究。这个神经网络的特点是在静息状态下具有同步且连贯的活动,它与自我反思、心理探索、社会互动和情绪处理有着内在联系。我们对默认模式网络的理解不仅限于人类,在非人类动物中也观察到了它,在各种物种中都有发现,这凸显了它在整个系统发育历史中的进化基础和适应性意义。此外,默认模式网络在儿童和青少年时期的大脑发育中起着至关重要的作用,影响着基本的认知和情感过程。这篇文献综述旨在全面概述默认模式网络,阐述其结构、功能和进化方面,以及从婴儿期到成年期的影响。通过更深入地了解默认模式网络的组织和功能,我们可以推进对认知、行为和心理健康背后神经机制的认识。反过来,这可以为一系列神经精神疾病带来更有效的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5181/12025022/4c98e1a1974f/biology-14-00395-g001.jpg

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