了解 T 细胞衰老以改善抗病毒免疫。
Understanding T cell aging to improve anti-viral immunity.
机构信息
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA; Department of Medicine, Veterans Administration Healthcare System, 3801 Miranda Ave, Palo Alto, CA 94304, USA.
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, USA.
出版信息
Curr Opin Virol. 2021 Dec;51:127-133. doi: 10.1016/j.coviro.2021.09.017. Epub 2021 Oct 21.
T cells are a critical component of the immune system and required for protection against viral and bacterial infections. However, the capacity of these cells to provide sufficient protection declines with age, leading to an increased susceptibility to and mortality from infection in older individuals. In many cases, it also contributes to poor vaccine-induced immunity. Understanding the basic biology behind T cell aging is key to unraveling these defects and, in turn, designing more effective vaccines and therapeutics for the older population. Here, we will discuss recent studies that have provided significant insight into the features of T cell aging, how these features may contribute to poor immune responses with advancing age and newer avenues of research that may further enhance anti-viral immunity in older individuals.
T 细胞是免疫系统的关键组成部分，对于预防病毒和细菌感染至关重要。然而，这些细胞提供充分保护的能力会随着年龄的增长而下降，导致老年人更容易感染和死于感染。在许多情况下，它也会导致疫苗诱导免疫的效果不佳。了解 T 细胞衰老背后的基本生物学原理是揭示这些缺陷的关键，进而为老年人设计更有效的疫苗和治疗方法。在这里，我们将讨论最近的研究，这些研究为 T 细胞衰老的特征提供了重要的见解，以及这些特征如何随着年龄的增长导致免疫反应不佳，并探讨了可能进一步增强老年人抗病毒免疫的新研究途径。
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