Institut Lavoisier de Versailles, CNRS UMR 8180, Univ. Versailles Saint Quentin en Yvelines, Université Paris-Saclay, 45 av. des Etats-Unis, 78035 Versailles, Cedex, France; State University of Moldova, 60 Alexei Mateevici str., MD-2009 Chisinau, Republic of Moldova.
Institut Lavoisier de Versailles, CNRS UMR 8180, Univ. Versailles Saint Quentin en Yvelines, Université Paris-Saclay, 45 av. des Etats-Unis, 78035 Versailles, Cedex, France.
J Inorg Biochem. 2022 Jan;226:111627. doi: 10.1016/j.jinorgbio.2021.111627. Epub 2021 Oct 16.
This paper deals with the biological potential of coordination compounds based on binuclear core [MoOE] (E = O or S) coordinated with commercially available ligands such as oxalates (Ox), L-cysteine (L-cys), L-histidine (L-his), Iminodiacetate (IDA), Nitrilotriacetate (HNTA or NTA) or ethylenediamine tetraacetate (EDTA) by means of various in vitro assays in a screening approach. Results suggest that the obtained complexes show weak antibacterial and antifungal properties while not being cytotoxic on cancerous and mammalian cells. In contrast, [MoOE(L-cys)] complexes stand out as powerful antioxidant, whereas [MoOE(EDTA)] associating tetraphenylphosphonium counter-cations display strong antibiotic activity. Finally, some complexes have evidenced a positive activity towards the growing of spirulina platensis together with a modification of the proportions of biological components inside the cells. These findings reveal promising bioactivity of the bridged binuclear Mo cores inside complexes and encourage further research for new highly active yet non-toxic molecules for biological and biomedical applications.
本文研究了基于双核核心 [MoOE]（E=O 或 S）的配合物的生物学潜力，该双核核心与市售配体如草酸盐 (Ox)、L-半胱氨酸 (L-cys)、L-组氨酸 (L-his)、亚氨基二乙酸 (IDA)、氮川三乙酸 (HNTA 或 NTA) 或乙二胺四乙酸 (EDTA) 通过各种体外筛选方法进行配位。结果表明，所获得的配合物表现出较弱的抗菌和抗真菌特性，同时对癌细胞和哺乳动物细胞没有细胞毒性。相比之下，[MoOE(L-cys)]配合物具有很强的抗氧化活性，而[MoOE(EDTA)]与四苯基膦抗衡阳离子结合则显示出很强的抗生素活性。最后，一些配合物对螺旋藻的生长表现出积极的活性，同时改变了细胞内生物成分的比例。这些发现表明桥联双核 Mo 核内配合物具有有前途的生物活性，并鼓励进一步研究用于生物和生物医学应用的新型高活性但无毒的分子。
