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静息态 fMRI 功能连接强度可预测背侧扣带回皮质局部活动变化：一项多靶点聚焦 rTMS 研究。

Resting-State fMRI Functional Connectivity Strength Predicts Local Activity Change in the Dorsal Cingulate Cortex: A Multi-Target Focused rTMS Study.

机构信息

Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.

Institute of Psychological Sciences, Hangzhou Normal University, Hangzhou 311121, China.

出版信息

Cereb Cortex. 2022 Jun 16;32(13):2773-2784. doi: 10.1093/cercor/bhab380.

DOI:10.1093/cercor/bhab380
PMID:34689201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9247427/
Abstract

Previous resting state functional magnetic resonance imaging (RS-fMRI) studies suggested that repetitive transcranial magnetic stimulation (rTMS) can modulate local activity in distant areas via functional connectivity (FC). A brain region has more than one connection with the superficial cortical areas. The current study proposed a multi-target focused rTMS protocol for indirectly stimulating a deep region, and to investigate 1) whether FC strength between stimulation targets (right middle frontal gyrus [rMFG] and right inferior parietal lobule [rIPL]) and effective region (dorsal anterior cingulate cortex [dACC]) can predict local activity changes of dACC and 2) whether multiple stimulation targets can focus on the dACC via FC. A total of 24 healthy participants received rTMS with two stimulation targets, both showing strong FC with the dACC. There were four rTMS conditions (>1 week apart, 10 Hz, 1800 pulses for each): rMFG-target, rIPL-target, Double-targets (900 pulses for each target), and Sham. The results failed to validate the multi-target focused rTMS hypothesis. But rMFG-target significantly decreased the local activity in the dACC. In addition, stronger dACC-rMFG FC was associated with a greater local activity change in the dACC. Future studies should use stronger FC to focus stimulation effects on the deep region.

摘要

先前的静息态功能磁共振成像 (RS-fMRI) 研究表明，重复经颅磁刺激 (rTMS) 可以通过功能连接 (FC) 调节远距离区域的局部活动。一个脑区与浅皮质区域有多个连接。本研究提出了一种多靶点聚焦 rTMS 方案，用于间接刺激深部区域，并探讨 1）刺激靶点（右侧额中回[rMFG]和右侧顶下小叶[rIPL]）与有效区域（背侧前扣带皮质[dACC]）之间的 FC 强度是否可以预测 dACC 的局部活动变化，以及 2）多个刺激靶点是否可以通过 FC 集中于 dACC。共 24 名健康参与者接受了两种刺激靶点的 rTMS 刺激，两者均与 dACC 具有强烈的 FC。共有四种 rTMS 条件（间隔>1 周，10Hz，每个靶点 1800 个脉冲）：rMFG-靶点、rIPL-靶点、双靶点（每个靶点 900 个脉冲）和假刺激。结果未能验证多靶点聚焦 rTMS 假说。但 rMFG-靶点显著降低了 dACC 的局部活动。此外，dACC-rMFG FC 越强，dACC 的局部活动变化越大。未来的研究应该使用更强的 FC 将刺激效果集中在深部区域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc9/9247427/0bc2e41e0ed6/bhab380f6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc9/9247427/2e412760f79a/bhab380f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc9/9247427/0bc2e41e0ed6/bhab380f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc9/9247427/0bf30ad6ec27/bhab380f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc9/9247427/49e684be3e17/bhab380f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc9/9247427/717cc498fad8/bhab380f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc9/9247427/f07a2cef811c/bhab380f4.jpg
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