Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Institute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Neuroinformatics. 2022 Oct;20(4):1055-1064. doi: 10.1007/s12021-022-09585-4. Epub 2022 May 24.
Resting-state magnetic resonance imaging (RS-fMRI) studies indicated that the repetitive transcranial magnetic stimulation (rTMS) exerts antidepression effect through the functional connectivity (FC) of the DLPFC with the subgenual anterior cingulate cortex (sgACC), pregneual ACC (pgACC), or nucleus accumbens (NAc). It is proposed that the FC-guided individualized precise stimulation on the DLPFC would be more effective. The current study systematically investigated the reliability of the RS-fMRI FC location as well as the FC strength with multiple potential factors. We aimed to provide a stable stimulation target for future FC-guided TMS therapy for affective related disorders. Twenty-one subjects under RS-fMRI conditions with the first two times (V1, V2) scanned on a GE 3 T scanner and the third visit (V3) on a Siemens 3 T scanner. Then the FC strength and location reliability were assessed by using intra-class correlation (ICC) and intra-individual distance, respectively. The factors included deep seed ROIs (midline (mid-) sgACC, left pgACC, mid-pgACC, and left NAc), eyes closed (EC) vs eyes open (EO), frequency bands, FC algorithm (Pearson vs Spearman), scanning length (half a session vs whole session), and location method (FC peak vs center of gravity (COG)). The reliability of the voxel-wise FC strength was low to moderate. The intra-individual distances of the COG were 3.8-7.3 mm across all factors, much smaller than that of FC peak (approximately 30 mm). The COG of seed-based FC might be a potential rTMS stimulation target. Anyway, all potential stimulation targets should be tested in future rTMS treatment studies.
静息态磁共振成像 (RS-fMRI) 研究表明，重复经颅磁刺激 (rTMS) 通过背外侧前额叶皮质 (DLPFC) 与前扣带回亚皮质 (sgACC)、扣带回前皮质 (pgACC) 或伏隔核 (NAc) 的功能连接 (FC) 发挥抗抑郁作用。有人提出，对 DLPFC 进行基于 FC 的个体化精确刺激会更有效。本研究系统地研究了 RS-fMRI FC 位置以及与多个潜在因素相关的 FC 强度的可靠性。我们旨在为未来基于 FC 的 TMS 治疗情感相关障碍提供一个稳定的刺激靶点。21 名受试者在 RS-fMRI 条件下，前两次（V1、V2）在 GE 3T 扫描仪上扫描，第三次（V3）在西门子 3T 扫描仪上扫描。然后分别采用组内相关系数 (ICC) 和个体内距离评估 FC 强度和位置的可靠性。这些因素包括深部种子 ROI（中线 (mid-) sgACC、左侧 pgACC、中 pgACC 和左侧 NAc）、闭眼 (EC) 与睁眼 (EO)、频带、FC 算法（Pearson 与 Spearman）、扫描长度（半程与全程）和定位方法（FC 峰值与重心 (COG)）。体素水平 FC 强度的可靠性为低至中度。所有因素的 COG 个体内距离为 3.8-7.3mm，明显小于 FC 峰值（约 30mm）。基于种子的 FC 的 COG 可能是 rTMS 刺激的潜在靶点。无论如何，所有潜在的刺激靶点都应在未来的 rTMS 治疗研究中进行测试。
