抑郁与海马神经发生：通往缓解的道路？
Depression and hippocampal neurogenesis: a road to remission?
机构信息
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.
出版信息
Science. 2012 Oct 5;338(6103):72-5. doi: 10.1126/science.1222941.
Abstract
Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new neurons to treat mood disorders such as depression. However, conflicting findings from preclinical research--involving stress, depression, and neurogenesis--highlight the complexity of considering neurogenesis as a road to remission from depression. To reconcile differences in the literature, we introduce the "neurogenic interactome," a platform from which to consider the diverse and dynamic factors regulating neurogenesis. We propose consideration of the varying perspectives--system, region, and local regulation of neurogenesis--offered by the interactome and exchange of ideas between the fields of learning and memory and mood disorder research to clarify the role of neurogenesis in the etiology and treatment of depression.
摘要
成年生成的海马神经元对于情绪控制和抗抑郁功效至关重要，这让人燃起了希望，也许有一天我们可以利用新神经元的力量来治疗情绪障碍，如抑郁症。然而，来自临床前研究的相互矛盾的发现——涉及应激、抑郁和神经发生——突出了将神经发生视为从抑郁中缓解的复杂性。为了调和文献中的差异，我们引入了“神经发生相互作用组”，这是一个可以考虑调节神经发生的多样化和动态因素的平台。我们建议考虑相互作用组提供的神经发生的不同视角——系统、区域和局部调节，并在学习和记忆领域与情绪障碍研究之间交流思想，以阐明神经发生在抑郁症的病因和治疗中的作用。
相似文献
1
Depression and hippocampal neurogenesis: a road to remission?抑郁与海马神经发生：通往缓解的道路？
Science. 2012 Oct 5;338(6103):72-5. doi: 10.1126/science.1222941.
2
Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression.抑郁的新生神经元——成体海马神经发生与重度抑郁症的细胞可塑性假说
Biol Psychiatry. 2003 Sep 1;54(5):499-503. doi: 10.1016/s0006-3223(03)00319-6.
3
Major depression: a role for hippocampal neurogenesis?重度抑郁症：海马体神经发生的作用？
Curr Top Behav Neurosci. 2013;14:153-79. doi: 10.1007/7854_2012_226.
4
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior.神经营养因子在成体海马神经发生、抗抑郁治疗及类抑郁行为动物模型中的作用
Behav Pharmacol. 2007 Sep;18(5-6):391-418. doi: 10.1097/FBP.0b013e3282ee2aa8.
5
Regulation of adult hippocampal neurogenesis - implications for novel theories of major depression.成年海马神经发生的调节——对重度抑郁症新理论的启示
Bipolar Disord. 2002 Feb;4(1):17-33. doi: 10.1034/j.1399-5618.2002.40101.x.
6
Implications of adult hippocampal neurogenesis in antidepressant action.成年海马神经发生在抗抑郁作用中的意义。
J Psychiatry Neurosci. 2004 May;29(3):196-205.
7
Is neurogenesis relevant in depression and in the mechanism of antidepressant drug action? A critical review.神经发生与抑郁症及抗抑郁药作用机制的关系：批判性综述。
World J Biol Psychiatry. 2012 Sep;13(6):402-12. doi: 10.3109/15622975.2011.639800. Epub 2011 Dec 19.
8
The Entorhinal Cortex and Adult Neurogenesis in Major Depression.内侧嗅皮层和重度抑郁症中的成年神经发生。
Int J Mol Sci. 2021 Oct 29;22(21):11725. doi: 10.3390/ijms222111725.
9
Deletion of TLX and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus.TLX 缺失和社会隔离会损害青少年海马体的运动诱导神经发生。
Hippocampus. 2018 Jan;28(1):3-11. doi: 10.1002/hipo.22805. Epub 2017 Oct 13.
10
Regulation of adult hippocampal neurogenesis: relevance to depression.成年海马神经发生的调节：与抑郁症的相关性。
Expert Rev Neurother. 2007 Jul;7(7):853-64. doi: 10.1586/14737175.7.7.853.
引用本文的文献
1
Calpain-1 and Calpain-2 in the Brain: What Have We Learned from 45 Years of Research?大脑中的钙蛋白酶-1和钙蛋白酶-2：45年研究我们学到了什么？
Cells. 2025 Aug 22;14(17):1301. doi: 10.3390/cells14171301.
2
Nutraceuticals: using food to enhance brain health by modulating postnatal neurogenesis in animal models and patient populations.营养保健品：通过调节动物模型和患者群体的产后神经发生来利用食物增强大脑健康。
Stem Cells Transl Med. 2025 May 19;14(5). doi: 10.1093/stcltm/szaf006.
3
Obesity-Related Differences in Amygdala and Hippocampus Volume and Metabolism in Major Depressive Disorder: Implications for Antidepressant Treatment.重度抑郁症中杏仁核和海马体体积及代谢与肥胖相关的差异：对抗抑郁治疗的启示
Res Sq. 2025 May 8:rs.3.rs-6257703. doi: 10.21203/rs.3.rs-6257703/v1.
4
Quercetin Improves Hippocampal Neurogenesis in Depression by Regulating the Level of Let-7e-5p in Microglia Exosomes.槲皮素通过调节小胶质细胞外泌体中Let-7e-5p的水平改善抑郁症中的海马神经发生。
Drug Des Devel Ther. 2025 Mar 24;19:2189-2203. doi: 10.2147/DDDT.S493779. eCollection 2025.
5
Impact of Neuroimmune System Activation by Adolescent Binge Alcohol Exposure on Adult Neurobiology.青少年暴饮酒精暴露激活神经免疫系统对成年神经生物学的影响。
Adv Exp Med Biol. 2025;1473:179-208. doi: 10.1007/978-3-031-81908-7_9.
6
An antidepressant mechanism underlying the allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons.一种基于对GABA能中间神经元中含GluN2D的NMDA受体进行变构抑制的抗抑郁机制。
Sci Adv. 2025 Mar 7;11(10):eadq0444. doi: 10.1126/sciadv.adq0444. Epub 2025 Mar 5.
7
Effects of Exercise on Post-Stroke Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.运动对中风后抑郁的影响：随机对照试验的系统评价和荟萃分析
Life (Basel). 2025 Feb 12;15(2):285. doi: 10.3390/life15020285.
8
Mitochondrial Transplantation in Animal Models of Psychiatric Disorders: A Novel Approach to Psychiatric Treatment.精神疾病动物模型中的线粒体移植：一种精神疾病治疗的新方法。
Biomolecules. 2025 Jan 27;15(2):184. doi: 10.3390/biom15020184.
9
Curcumin and exercise prevent depression alleviating hippocampus injury and improve depressive-like behaviors in chronically stressed depression rats.姜黄素和运动可预防抑郁症，减轻海马体损伤，并改善慢性应激性抑郁症大鼠的抑郁样行为。
Res Pharm Sci. 2024 Oct 22;19(5):509-519. doi: 10.4103/RPS.RPS_94_23. eCollection 2024 Oct.
10
Semen Cuscutae flavonoids activated the cAMP-PKA-CREB-BDNF pathway and exerted an antidepressant effect in mice.菟丝子黄酮激活cAMP-PKA-CREB-BDNF通路并对小鼠发挥抗抑郁作用。
Front Pharmacol. 2024 Nov 25;15:1491900. doi: 10.3389/fphar.2024.1491900. eCollection 2024.
本文引用的文献
1
Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression.在重度抑郁症中，使用抗抑郁药会增加海马血管生成和祖细胞增殖。
Biol Psychiatry. 2012 Oct 1;72(7):562-71. doi: 10.1016/j.biopsych.2012.04.024. Epub 2012 May 30.
2
Modifiable factors that alter the size of the hippocampus with ageing.可改变的因素会随着年龄的增长而改变海马体的大小。
Nat Rev Neurol. 2012 Mar 13;8(4):189-202. doi: 10.1038/nrneurol.2012.27.
3
Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion.年轻的颗粒细胞介导模式分离，而旧的颗粒细胞则促进模式完成。
Cell. 2012 Mar 30;149(1):188-201. doi: 10.1016/j.cell.2012.01.046. Epub 2012 Feb 23.
4
Can adult neurogenesis buffer stress responses and depressive behaviour?成年神经发生能否缓冲应激反应和抑郁行为？
Mol Psychiatry. 2012 Jan;17(1):9-10. doi: 10.1038/mp.2011.133. Epub 2011 Oct 11.
5
The neurogenesis hypothesis of affective and anxiety disorders: are we mistaking the scaffolding for the building?情感和焦虑障碍的神经发生假说：我们是否把脚手架误认为是建筑物？
Neuropharmacology. 2012 Jan;62(1):21-34. doi: 10.1016/j.neuropharm.2011.09.003. Epub 2011 Sep 19.
6
A pathophysiological framework of hippocampal dysfunction in ageing and disease.衰老和疾病中海马功能障碍的病理生理学框架。
Nat Rev Neurosci. 2011 Sep 7;12(10):585-601. doi: 10.1038/nrn3085.
7
Biomarkers of anhedonic-like behavior, antidepressant drug refraction, and stress resilience in a rat model of depression.抑郁模型大鼠快感缺失样行为、抗抑郁药物耐药和应激适应能力的生物标志物。
Neuroscience. 2011 Nov 24;196:66-79. doi: 10.1016/j.neuroscience.2011.08.024. Epub 2011 Aug 27.
8
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour.成年海马神经发生缓冲应激反应和抑郁行为。
Nature. 2011 Aug 3;476(7361):458-61. doi: 10.1038/nature10287.
9
Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons.基底外侧杏仁核调节成年海马神经发生和新生神经元的恐惧相关激活。
Mol Psychiatry. 2012 May;17(5):527-36. doi: 10.1038/mp.2011.71. Epub 2011 Jun 14.
10
Adult neurogenesis in the mammalian brain: significant answers and significant questions.哺乳动物大脑中的成人神经发生：重要的答案和重要的问题。
Neuron. 2011 May 26;70(4):687-702. doi: 10.1016/j.neuron.2011.05.001.
Zotero 插件