Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.
Science. 2012 Oct 5;338(6103):72-5. doi: 10.1126/science.1222941.
Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new neurons to treat mood disorders such as depression. However, conflicting findings from preclinical research--involving stress, depression, and neurogenesis--highlight the complexity of considering neurogenesis as a road to remission from depression. To reconcile differences in the literature, we introduce the "neurogenic interactome," a platform from which to consider the diverse and dynamic factors regulating neurogenesis. We propose consideration of the varying perspectives--system, region, and local regulation of neurogenesis--offered by the interactome and exchange of ideas between the fields of learning and memory and mood disorder research to clarify the role of neurogenesis in the etiology and treatment of depression.
成年生成的海马神经元对于情绪控制和抗抑郁功效至关重要，这让人燃起了希望，也许有一天我们可以利用新神经元的力量来治疗情绪障碍，如抑郁症。然而，来自临床前研究的相互矛盾的发现——涉及应激、抑郁和神经发生——突出了将神经发生视为从抑郁中缓解的复杂性。为了调和文献中的差异，我们引入了“神经发生相互作用组”，这是一个可以考虑调节神经发生的多样化和动态因素的平台。我们建议考虑相互作用组提供的神经发生的不同视角——系统、区域和局部调节，并在学习和记忆领域与情绪障碍研究之间交流思想，以阐明神经发生在抑郁症的病因和治疗中的作用。
