Musial Natalie, Ali Zinnia, Grbevski Jennifer, Veerakumar Ashan, Sharma Priya
Department of Psychiatry, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Focus (Am Psychiatr Publ). 2021 Jul;19(3):330-337. doi: 10.1176/appi.focus.20200041. Epub 2021 Jul 9.
Perimenopause is often a time of social, emotional, and physical change. Various factors contribute to the development of mood disorders during this time. There is a known association among women with previous history of major depressive disorder or bipolar disorder and relapse during the menopausal transition. First-onset mood disorders during this time have been less studied. A literature review in PsycInfo Ovid of records pertaining to first-onset mood disorders during perimenopause showed that this multifactorial process involves hormonal fluctuations, with estrogen being a key player. In addition, vasomotor symptoms, previous negative life events, and socioeconomic status were found to contribute to first-onset mood disorders during perimenopause. Treatment options include established medication regimens for psychiatric conditions; however, hormone therapy also has proven beneficial for this patient population. Further research, particularly on bipolar disorder, is needed to develop a clear association between perimenopause and first-onset mood disorders.
围绝经期通常是社会、情绪和身体发生变化的时期。在此期间，多种因素导致情绪障碍的发生。有重度抑郁症或双相情感障碍既往史的女性在绝经过渡期间复发的情况是已知的。这段时间首次发作的情绪障碍研究较少。对PsycInfo Ovid中有关围绝经期首次发作情绪障碍记录的文献综述表明，这个多因素过程涉及激素波动，其中雌激素起关键作用。此外，血管舒缩症状、既往负面生活事件和社会经济地位被发现与围绝经期首次发作情绪障碍有关。治疗选择包括既定的精神疾病药物治疗方案；然而，激素疗法对这一患者群体也已证明有益。需要进一步研究，尤其是关于双相情感障碍的研究，以明确围绝经期与首次发作情绪障碍之间的关联。
