Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
J Affect Disord. 2020 Jan 1;260:194-199. doi: 10.1016/j.jad.2019.09.008. Epub 2019 Sep 2.
To study the association of trans fatty acid intake from diet with depressive symptoms in midlife women.
Data for this cross-sectional study were retrieved from baseline assessment of the Study of Women's Health Across the Nation (SWAN). Linear regression, logistic regression and restricted cubic spline models were performed to examine the association trans fatty acid intake with depressive symptoms.
A total of 3095 women aged 42-52 years were included in the present study. Trans fatty acid intake was positively associated with CES-D (Center for Epidemiological Studies-Depression) scores in unadjusted, age-, race/ethnicity-, total family income- and education-adjusted and fully adjusted linear regression model. The fully adjusted regression coefficient with 95% confidence intervals (CIs) of trans fatty acid intake were 0.146 (0.047-0.246) for CES-D score. Trans fatty acid intake was positively associated with depressive symptoms (CES-D score ≥16) in each logistic regression model. The fully adjusted odds ratios (ORs) with 95% CI of depressive symptoms were 1.410 (1.019-1.951) in quartile 4 compared with quartile 1 for trans fatty acid intake. Sensitivity analyses showed that the association between trans fatty acid and depressive symptoms were not affected by use of antidepressant. Stratified analysis showed that, in fully adjusted model, the trans fatty acid intake was not significantly associated with depressive symptoms in early perimenopausal women.
This was a cross-sectional study, limiting causal inferences.
Trans fatty acid may be positively associated with depressive symptoms in premenopausal women, but not in early perimenopausal women.
研究饮食中反式脂肪酸摄入与中年女性抑郁症状的关系。
本横断面研究的数据来自妇女健康全国研究（SWAN）的基线评估。采用线性回归、逻辑回归和限制三次样条模型来研究反式脂肪酸摄入与抑郁症状的关系。
本研究共纳入 3095 名年龄在 42-52 岁的女性。在未调整、年龄、种族/民族、家庭总收入和教育程度调整以及完全调整的线性回归模型中，反式脂肪酸摄入与 CES-D（流行病学研究抑郁量表）评分呈正相关。反式脂肪酸摄入的完全调整回归系数及其 95%置信区间（CI）为 CES-D 评分 0.146（0.047-0.246）。在每个逻辑回归模型中，反式脂肪酸摄入与抑郁症状呈正相关（CES-D 评分≥16）。在反式脂肪酸摄入四分位 4 与 1 相比，完全调整后的比值比（OR）及其 95%CI 为 1.410（1.019-1.951）。敏感性分析表明，反式脂肪酸与抑郁症状之间的关联不受抗抑郁药物使用的影响。分层分析显示，在完全调整模型中，反式脂肪酸摄入与绝经前妇女的抑郁症状无显著相关性。
这是一项横断面研究，限制了因果推断。
反式脂肪酸可能与绝经前妇女的抑郁症状呈正相关，但与早期绝经后妇女的抑郁症状无关。
