Department of Thyroid and Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu, China.
Laboratory of Thyroid and Parathyroid Diseases, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Int J Public Health. 2021 Oct 6;66:1604371. doi: 10.3389/ijph.2021.1604371. eCollection 2021.
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new terminology updated from non-alcoholic fatty liver disease (NAFLD). We aim to estimate the global prevalence of MAFLD in overweight or obese children and adolescents, by repurposing existing data on fatty liver disease. We screened relevant articles published up to December 2020. Pooled prevalence was calculated using Logit transformations. Our search returned 35,441 records, of which 156 studies fulfilled the inclusion criteria. The overall prevalence of MAFLD was 33.78% in the general population and 44.94% in a special population based on child obesity clinics, regardless of the diagnostic techniques. For subgroup analysis, MAFLD prevalence was significantly higher in boys compared to girls (36.05 vs. 26.84% in the general population; 50.20 vs. 35.34% in the child obesity clinics-based population). Interestingly, based on study source, the pooled prevalence of MAFLD was 1.5-fold higher in other "fatty liver disease" studies compared to the classical "NAFLD" studies in the general population. MAFLD is highly prevalent in overweight or obese children and adolescents. Raising awareness and urgent actions are warranted to control the MAFLD pandemic across the globe.
代谢相关脂肪性肝病（MAFLD）是从非酒精性脂肪性肝病（NAFLD）更新的一个新术语。我们旨在通过重新利用现有的关于脂肪肝疾病的数据来估计超重或肥胖儿童和青少年中 MAFLD 的全球患病率。我们筛选了截至 2020 年 12 月发表的相关文章。使用 Logit 转换计算汇总患病率。我们的搜索返回了 35441 条记录，其中 156 项研究符合纳入标准。无论诊断技术如何，普通人群中 MAFLD 的总体患病率为 33.78%，特殊人群（基于儿童肥胖诊所）中 MAFLD 的患病率为 44.94%。对于亚组分析，与女孩相比，男孩中 MAFLD 的患病率明显更高（普通人群中为 36.05%比 26.84%；基于儿童肥胖诊所的人群中为 50.20%比 35.34%）。有趣的是，根据研究来源，在普通人群中，与经典的“NAFLD”研究相比，其他“脂肪肝疾病”研究中 MAFLD 的汇总患病率高 1.5 倍。MAFLD 在超重或肥胖的儿童和青少年中患病率很高。全球范围内需要提高认识并采取紧急行动来控制 MAFLD 大流行。
