Department of Otolaryngology, HwaMei Hospital, University of Chinese Academy of Sciences, China.
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dis Markers. 2021 Oct 13;2021:7897994. doi: 10.1155/2021/7897994. eCollection 2021.
The safety of radiotherapy techniques in the treatment of vestibular schwannoma (VS) shows a high rate of tumor control with few side effects. Neuropeptide Y (NPY) may have a potential relevance to the recurrence of VS. Further research is still needed on the key genes that determine the sensitivity of VS to radiation therapy.
Transcriptional microarray data and clinical information data from VS patients were downloaded from GSE141801, and vascular-related genes associated with recurrence after radiation therapy for VS were obtained by combining information from MSigDB. Logistics regression was applied to construct a column line graph prediction model for recurrence status after radiation therapy. Pan-cancer analysis was also performed to investigate the cooccurrence of these genes in tumorigenesis.
We identified eight VS recurrence-related genes from the GSE141801 dataset. All of these genes were highly expressed in the VS recurrence samples. Four collagen family genes (, , , and ) were further screened, and a model was constructed to predict the risk of recurrence of VS. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that these four collagen family genes play important roles in a variety of biological functions and cellular pathways. Pan-cancer analysis further revealed that the expression of these genes was significantly heterogeneous across immune phenotypes and significantly associated with immune infiltration. Finally, Neuropeptide Y (NPY) was found to be significantly and negatively correlated with the expression of , , and .
Four collagen family genes have been identified as possible predictors of recurrence after radiation therapy for VS. Pan-cancer analysis reveals potential associations between the pathogenesis of VS and other tumorigenic factors. The relevance of NPY to VS was also revealed for the first time.
放射治疗技术在治疗前庭神经鞘瘤（VS）方面的安全性具有较高的肿瘤控制率，副作用较少。神经肽 Y（NPY）可能与 VS 的复发有潜在关联。进一步研究确定 VS 对放射治疗敏感性的关键基因仍然是必要的。
从 GSE141801 下载 VS 患者的转录微阵列数据和临床信息数据，并结合 MSigDB 中的信息获得与 VS 放射治疗后复发相关的血管相关基因。应用逻辑回归构建放射治疗后复发状态的列线图预测模型。还进行了泛癌分析，以研究这些基因在肿瘤发生中的共同发生。
我们从 GSE141801 数据集确定了 8 个与 VS 复发相关的基因。所有这些基因在 VS 复发样本中均高度表达。进一步筛选了四个胶原家族基因（、、、和），并构建了一个预测 VS 复发风险的模型。基因本体论（GO）和京都基因与基因组百科全书（KEGG）富集分析表明，这四个胶原家族基因在多种生物学功能和细胞途径中发挥重要作用。泛癌分析进一步表明，这些基因的表达在免疫表型上存在显著异质性，并且与免疫浸润显著相关。最后，发现神经肽 Y（NPY）与、和的表达呈显著负相关。
鉴定出四个胶原家族基因可能是 VS 放射治疗后复发的预测因子。泛癌分析揭示了 VS 发病机制与其他肿瘤发生因素之间的潜在关联。首次揭示了 NPY 与 VS 的相关性。
