Adeyemi-Doro F A, Rotowa N A
Infection. 1986;14 Suppl 4:S240-2. doi: 10.1007/BF01661281.
The in vitro activity of ofloxacin (Hoe 280) against Staphylococcus aureus, some Enterobacteriaceae and Pseudomonas spp. is compared with that of gentamicin using the agar dilution method to determine the minimal inhibitory concentration of each agent for the isolates. Ofloxacin and gentamicin were found to have similar activity against Staphylococcus aureus with an MIC50 of 0.25 mg/l and an MIC90 of 1.0 mg/l. However, ofloxacin appears to be more active against the Enterobacteriaceae than gentamicin with lower MICs for some species of that family. Ofloxacin was found to have an MIC50 value of 0.25 mg/l for the Enterobacteriaceae and an MIC90 of 1.0 mg/l while the MIC90 of gentamicin for the same isolates was 32.0 mg/l. A significant proportion of our Pseudomonas spp. were resistant to gentamicin with an MIC90 of over 16 mg/l and a range of 0.5 mg/l to greater than 128 mg/l. Ofloxacin had an MIC range of 0.25 to 4.0 mg/l for the same organisms.
采用琼脂稀释法测定氧氟沙星（Hoe 280）对金黄色葡萄球菌、部分肠杆菌科细菌和假单胞菌属细菌的体外活性，并与庆大霉素进行比较，以确定每种药物对分离菌株的最低抑菌浓度。结果发现，氧氟沙星和庆大霉素对金黄色葡萄球菌的活性相似，MIC50为0.25mg/L，MIC90为1.0mg/L。然而，氧氟沙星对肠杆菌科细菌的活性似乎比庆大霉素更强，对该科某些菌种的MIC较低。对于肠杆菌科细菌，氧氟沙星的MIC50值为0.25mg/L，MIC90为1.0mg/L，而庆大霉素对相同分离菌株的MIC90为32.0mg/L。我们分离的假单胞菌属细菌中有很大一部分对庆大霉素耐药，MIC90超过16mg/L，范围为0.5mg/L至大于128mg/L。对于相同的菌株，氧氟沙星的MIC范围为0.25至4.0mg/L。
