Forgan-Smith W R, McSweeney R J
Aust N Z J Med. 1978 Aug;8(4):383-6. doi: 10.1111/j.1445-5994.1978.tb04906.x.
The in vitro antimicrobial activities of gentamicin and amikacin against 1000 bacterial isolates from clinical material were compared. The minimum inhibitory concentrations were determined by an agar dilution technique. Both of these aminoglycoside antibiotics had a similar spectrum of activity, being highly active against most species of aerobic Gram negative bacilli. Gentamicin was more active than amikacin against most species of enterobacteria, Haemophilus influenzae and Staphylococcus aureus but amikacin was more active against a proportion of Klebsiella and Providencia isolates. For most isolates, the differences in activity between gentamicin and amikacin were small, however, amikacin achieves higher serum levels. Most resistant isolates in this survey did not influence patient mortality.
比较了庆大霉素和阿米卡星对1000株临床分离菌的体外抗菌活性。采用琼脂稀释法测定最低抑菌浓度。这两种氨基糖苷类抗生素具有相似的活性谱，对大多数需氧革兰氏阴性杆菌具有高度活性。庆大霉素对大多数肠杆菌科细菌、流感嗜血杆菌和金黄色葡萄球菌的活性比阿米卡星更强，但阿米卡星对部分克雷伯菌属和普罗威登斯菌属分离株的活性更强。对于大多数分离株，庆大霉素和阿米卡星之间的活性差异较小，然而，阿米卡星可达到更高的血清浓度。本次调查中大多数耐药分离株并未影响患者死亡率。
