Mraović M, Canić-Radojlović M
Infection. 1986;14 Suppl 4:S231-2. doi: 10.1007/BF01661278.
The return of multiresistant Staphylococcus aureus strains and the appearance of methicillin-resistant strains resistant as well to rifampin and fusidic acid increase the need for new agents to treat infections caused by such strains. Ofloxacin susceptibility of 109 selected methicillin-resistant staphylococci (with MIC90 of 1,000 mg/l for methicillin, 1.3% being resistant to gentamicin with MICs ranging from 25 to 100 mg/l, chloramphenicol MICs ranging from 25 to 100 mg/l and resistant to beta-lactam-antibiotics and clindamycin), was determined by an agar dilution method. MICs of ofloxacin for methicillin-resistant staphylococci ranged from 0.09 to 0.78 mg/l, with an MIC90 of 0.39 mg/l. The in vitro results suggest a possible clinical role for ofloxacin in infections caused by methicillin-resistant staphylococci. However, further investigations are needed.
多重耐药金黄色葡萄球菌菌株的出现以及对利福平和夫西地酸也耐药的耐甲氧西林菌株的出现，增加了对治疗此类菌株引起感染的新型药物的需求。采用琼脂稀释法测定了109株选定的耐甲氧西林葡萄球菌（甲氧西林的MIC90为1000mg/L，对庆大霉素耐药的占1.3%，MIC范围为25至100mg/L，氯霉素MIC范围为25至100mg/L，对β-内酰胺类抗生素和克林霉素耐药）对氧氟沙星的敏感性。耐甲氧西林葡萄球菌对氧氟沙星的MIC范围为0.09至0.78mg/L，MIC90为0.39mg/L。体外研究结果提示氧氟沙星在耐甲氧西林葡萄球菌引起的感染中可能具有临床应用价值。然而，仍需进一步研究。
