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Accelerated passage of gene-modified monkeys by hormone-induced precocious puberty.

作者信息

Liu Zhen, Li Kui, Cai Yijun, Liu Qiming, Zhang Tikui, Lu Yong, Nie Yanhong, Wang Yan, Yan Zhiguang, Qu Yinwei, Li Yuzhuo, Wang Zhanyang, Xiong Zhi-Qi, Sun Qiang

机构信息

Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, China.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, China.

出版信息

Natl Sci Rev. 2021 May 4;8(7):nwab083. doi: 10.1093/nsr/nwab083. eCollection 2021 Jul.

DOI:10.1093/nsr/nwab083
PMID:34691699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8310752/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0e/8310752/288750a5ab64/nwab083fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0e/8310752/288750a5ab64/nwab083fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0e/8310752/288750a5ab64/nwab083fig1.jpg

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One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs.通过CRISPR/Cas9介导的多sgRNA基因编辑一步生成完全基因敲除小鼠和猴子。
Cell Res. 2017 Jul;27(7):933-945. doi: 10.1038/cr.2017.81. Epub 2017 Jun 6.
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Opportunities and challenges in modeling human brain disorders in transgenic primates.转基因灵长类动物模型人类脑疾病的机遇与挑战。
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Emerg Microbes Infect. 2021 Dec;10(1):1881-1889. doi: 10.1080/22221751.2021.1976598.
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Functional assessment of sexual maturity in male macaques (Macaca fascicularis).雄性猕猴（Macaca fascicularis）性成熟度的功能评估。
Regul Toxicol Pharmacol. 2012 Aug;63(3):391-400. doi: 10.1016/j.yrtph.2012.05.003. Epub 2012 May 10.
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Methods for predicting sexual maturity in male cynomolgus macaques on the basis of age, body weight, and histologic evaluation of the testes.基于年龄、体重和睾丸组织学评估预测雄性食蟹猴性成熟的方法。
Contemp Top Lab Anim Sci. 2002 Sep;41(5):18-20.
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FSH and testosterone, alone or in combination, initiate testicular growth and increase the number of spermatogonia and Sertoli cells in a juvenile non-human primate (Macaca mulatta).促卵泡生成素（FSH）和睾酮单独或联合使用，均可启动幼年非人灵长类动物（猕猴）的睾丸生长，并增加精原细胞和支持细胞的数量。
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Testosterone can initiate spermatogenesis in an immature nonhuman primate, Macaca fascicularis.睾酮可在未成熟的食蟹猴（猕猴属）中启动精子发生。
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Accuracy and precision of computer-aided sperm analysis in multicenter studies.多中心研究中计算机辅助精子分析的准确性和精密度
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