Li Jianbin, Ma Li, Zou Minghui, Li Wenlei, Chen Xinxin, Cui Yanqin, Hu Xiaoyan
Heart Center, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Department of Paediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Cardiol Res Pract. 2021 Oct 15;2021:3300884. doi: 10.1155/2021/3300884. eCollection 2021.
To assess the value of N-terminal probrain natriuretic peptide (NT-proBNP) in short-term and long-term follow-up after a modified Fontan procedure.
We retrospectively enrolled children who had undergone a modified Fontan procedure in the Heart Center of Guangzhou Women and Children's Medical Center from January 2014 to September 2020 and collected data on NT-proBNP values before bidirectional Glenn procedure, before Fontan procedure, and on 1, 3, 7, 30, 90, and 180 days and 1, 2, 3, 4, 5, and 6 year after Fontan procedure. The relationship between changes in NT-proBNP levels and the outcomes in children was analyzed.
A total of 108 children (78 boys and 30 girls, mean age: 54.62 ± 29.38 weeks) were included in the analysis. According to one-way analysis of variance, the left ventricular type and biventricular type of single ventricle physiology showed shorter duration on cardiopulmonary bypass during the operation and lower levels of NT-proBNP after the operation than the right ventricular type and univentricular type physiology.
NT-proBNP is a good indicator for mid and long-term follow-up after a modified Fontan procedure. The left ventricular type and biventricular type of single ventricle physiology show better mid and long-term benefits from the modified Fontan procedure than the right ventricular type and univentricular type physiology.
评估N端前脑钠肽（NT-proBNP）在改良Fontan手术短期和长期随访中的价值。
我们回顾性纳入了2014年1月至2020年9月在广州市妇女儿童医疗中心心脏中心接受改良Fontan手术的儿童，并收集了双向Glenn手术前、Fontan手术前以及Fontan手术后1、3、7、30、90和180天以及1、2、3、4、5和6年的NT-proBNP值数据。分析了儿童NT-proBNP水平变化与预后之间的关系。
共有108名儿童（78名男孩和30名女孩，平均年龄：54.62±29.38周）纳入分析。根据单因素方差分析，单心室生理的左心室型和双心室型在手术期间体外循环时间较短，术后NT-proBNP水平低于右心室型和单心室型生理。
NT-proBNP是改良Fontan手术后中长期随访的良好指标。单心室生理的左心室型和双心室型从改良Fontan手术中获得的中长期益处优于右心室型和单心室型生理。
