亚胺培南在择期结直肠手术中的药代动力学

Imipenem pharmacokinetics in elective colorectal surgery.

作者信息

Gartell P C, Sutton G L, Eardley I, Porte M, Taylor E A

出版信息

J Antimicrob Chemother. 1986 Dec;18 Suppl E:109-13. doi: 10.1093/jac/18.supplement_e.109.

DOI:10.1093/jac/18.supplement_e.109

Abstract

A study of the pharmacokinetics of imipenem in 22 patients undergoing elective colorectal surgery was performed. Samples of plasma, fat, muscle and viscera were assayed at various intervals following intravenous injection of 1 g imipenem and 1 g cilastatin. The concentration of imipenem in plasma was approximately ten times that found in the tissues. The half-life was similar in plasma, muscle and fat (approximately 1 h). Visceral levels showed a slower fall (T 1/2 83 min). Plasma and tissue levels exceeded the MIC90 for all common pathogens for at least the first two hours of surgery. We conclude that imipenem is a suitable agent for antibiotic prophylaxis in colorectal surgery.

摘要

对22例行择期结肠直肠手术的患者进行了亚胺培南药代动力学研究。静脉注射1 g亚胺培南和1 g西司他丁后，在不同时间间隔采集血浆、脂肪、肌肉和内脏样本进行检测。血浆中亚胺培南的浓度约为组织中浓度的10倍。血浆、肌肉和脂肪中的半衰期相似（约1小时）。内脏水平下降较慢（T1/2 83分钟）。血浆和组织水平在手术的至少前两小时内超过了所有常见病原体的MIC90。我们得出结论，亚胺培南是结肠直肠手术中抗生素预防的合适药物。