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为什么热量限制会延长寿命和健康寿命？“清理橱柜”假说。

Why does caloric restriction increase life and healthspan? The 'clean cupboards' hypothesis.

作者信息

Speakman John R

机构信息

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, China.

出版信息

Natl Sci Rev. 2020 Jul;7(7):1153-1156. doi: 10.1093/nsr/nwaa078. Epub 2020 Apr 29.

DOI:10.1093/nsr/nwaa078
PMID:34692140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8288867/
Abstract

The disposable soma hypothesis explanation of the effects of caloric restriction (CR) on lifespan fails to explain why CR generates negative impacts alongside the positive effects and does not work in all species. I propose here a novel idea called the clean cupboards hypothesis which overcomes these problems.

摘要

关于热量限制（CR）对寿命影响的一次性体细胞假说解释，无法解释为何热量限制在产生积极影响的同时还会带来负面影响，且并非对所有物种都有效。我在此提出一个名为“清理橱柜假说”的新观点，该观点克服了这些问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/8288867/a86988bd6379/nwaa078fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/8288867/3bd102bb43b9/nwaa078fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/8288867/9d5c3d63d438/nwaa078fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/8288867/a86988bd6379/nwaa078fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/8288867/3bd102bb43b9/nwaa078fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/8288867/9d5c3d63d438/nwaa078fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a80d/8288867/a86988bd6379/nwaa078fig3.jpg

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本文引用的文献

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The effect of fasting or calorie restriction on autophagy induction: A review of the literature.禁食或热量限制对自噬诱导的影响：文献综述。
Ageing Res Rev. 2018 Nov;47:183-197. doi: 10.1016/j.arr.2018.08.004. Epub 2018 Aug 30.
3
The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon.热量限制的影响：十二、小鼠与人结肠细胞衰老的比较。
限制热量摄入对小鼠的益处是通过能量失衡介导的，而不是绝对能量或蛋白质摄入。
Geroscience. 2024 Oct;46(5):4809-4826. doi: 10.1007/s11357-024-01166-4. Epub 2024 Jun 8.
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The Potential of Fasting-Mimicking Diet as a Preventive and Curative Strategy for Alzheimer's Disease.间歇性禁食模拟饮食作为阿尔茨海默病预防和治疗策略的潜力。
Biomolecules. 2023 Jul 14;13(7):1133. doi: 10.3390/biom13071133.
5
Energy Allocation of the Wolf Spider under Dietary Restriction.饮食限制下狼蛛的能量分配
Insects. 2023 Jun 25;14(7):579. doi: 10.3390/insects14070579.
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