Noguchi Memorial Institute for Medical Research, Department of Parasitology, University of Ghana, Accra, Ghana.
Noguchi Memorial Institute for Medical Research, Department of Immunology, University of Ghana, Accra, Ghana.
Front Cell Infect Microbiol. 2021 Oct 7;11:741370. doi: 10.3389/fcimb.2021.741370. eCollection 2021.
Cerebral malaria (CM) is a severe neurological complication of malaria caused by the parasite. It is one of the leading causes of death in children under 5 years of age in Sub-Saharan Africa. CM is associated with blood-brain barrier disruption and long-term neurological sequelae in survivors of CM. Despite the vast amount of research on cerebral malaria, the cause of neurological sequelae observed in CM patients is poorly understood. In this article, the potential roles of glial cells, astrocytes, and microglia, in cerebral malaria pathogenesis are reviewed. The possible mechanisms by which glial cells contribute to neurological damage in CM patients are also examined.
脑型疟疾（CM）是由寄生虫引起的疟疾的一种严重神经并发症。它是撒哈拉以南非洲地区 5 岁以下儿童死亡的主要原因之一。CM 与血脑屏障破坏和 CM 幸存者的长期神经后遗症有关。尽管对脑型疟疾进行了大量研究，但对 CM 患者中观察到的神经后遗症的原因仍了解甚少。在本文中，回顾了神经胶质细胞、星形胶质细胞和小胶质细胞在脑型疟疾发病机制中的潜在作用。还检查了神经胶质细胞在 CM 患者神经损伤中发挥作用的可能机制。
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