School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.
Beijing School of Chemistry and Bioengineering, University of Science and Technology Beijing, Beijing, China.
Front Cell Infect Microbiol. 2022 Jul 25;12:939532. doi: 10.3389/fcimb.2022.939532. eCollection 2022.
Cerebral malaria (CM) caused by is a fatal neurological complication of malaria, resulting in coma and death, and even survivors may suffer long-term neurological sequelae. In sub-Saharan Africa, CM occurs mainly in children under five years of age. Although intravenous artesunate is considered the preferred treatment for CM, the clinical efficacy is still far from satisfactory. The neurological damage induced by CM is irreversible and lethal, and it is therefore of great significance to unravel the exact etiology of CM, which may be beneficial for the effective management of this severe disease. Here, we review the clinical characteristics, pathogenesis, diagnosis, and clinical therapy of CM, with the aim of providing insights into the development of novel tools for improved CM treatments.
脑型疟疾（CM）由 引起，是疟疾的一种致命性神经并发症，可导致昏迷和死亡，即使幸存者也可能遭受长期的神经后遗症。在撒哈拉以南非洲地区，CM 主要发生在五岁以下儿童中。虽然静脉注射青蒿琥酯被认为是 CM 的首选治疗方法，但临床疗效仍远未令人满意。CM 引起的神经损伤是不可逆的和致命的，因此揭示 CM 的确切病因具有重要意义，这可能有助于有效管理这种严重疾病。在这里，我们综述了 CM 的临床特征、发病机制、诊断和临床治疗，旨在为开发新型工具以改善 CM 治疗提供思路。
