Meshkini Ali, Ghorbani Haghjo Amir, Hasanpour Segherlou Zahra, Nouri-Vaskeh Masoud
Road Injuries Prevention Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Bull Emerg Trauma. 2021 Oct;9(4):183-187. doi: 10.30476/BEAT.2021.89355.1231.
To examine the GFAP and S100B ability in prevention unnecessary brain Computed tomography (CT) scan in mild traumatic brain injury (mTBI) and compare them with the single extremity fracture in orthopedic patients.
In this prospective cohort study, two orthopedics patients' groups and mTBI patients were studied to assess the biomarkers' ability in prevention unnecessary brain CT scan at the emergency setting. There were 40 orthopedics' patients with single extremity fracture and 41 mTBI patients. Brain CT scans were done for all mTBI patients.
Brain CT scans showed no intracranial traumatic lesions. The median levels for S100B in the mTBI group was 14.8 (4.4-335.9) ng/L, and in orthopedic patients' group was 13.3 (5-353.10) ng/L. Statistically significant differences were observed between both groups in S100B levels (=0.006). The median Glial Fibrillary Acidic Protein (GFAP) levels in the mTBI patients' group were 600 (400-16300) and in the orthopedic patients' groups was 60 ng/L (300-14900). Statistically significant differences were observed between groups in GFAP (=0.041).
Our results showed that S100B and GFAP serum levels were significantly higher in patients with mTBI than in patients with a single limb fracture.
研究胶质纤维酸性蛋白（GFAP）和S100B蛋白在预防轻度创伤性脑损伤（mTBI）患者进行不必要的脑部计算机断层扫描（CT）中的作用，并将其与骨科单肢骨折患者进行比较。
在这项前瞻性队列研究中，对两组骨科患者和mTBI患者进行研究，以评估生物标志物在急诊情况下预防不必要脑部CT扫描的能力。有40例单肢骨折的骨科患者和41例mTBI患者。所有mTBI患者均进行了脑部CT扫描。
脑部CT扫描显示无颅内创伤性病变。mTBI组中S100B的中位数水平为14.8（4.4 - 335.9）ng/L，骨科患者组为13.3（5 - 353.10）ng/L。两组之间S100B水平存在统计学显著差异（P = 0.006）。mTBI患者组中胶质纤维酸性蛋白（GFAP）的中位数水平为600（400 - 16300），骨科患者组为60 ng/L（300 - 14900）。两组之间GFAP存在统计学显著差异（P = 0.041）。
我们的结果表明，mTBI患者的S100B和GFAP血清水平显著高于单肢骨折患者。
