Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Head Neck. 2022 Jan;44(1):177-188. doi: 10.1002/hed.26906. Epub 2021 Oct 25.
High-risk human papillomaviruses (HR HPV) cause nearly all cervical cancers and, in the United States, the majority of head and neck cancers (HNSCCs). NFX1-123 is overexpressed in cervical cancers, and NFX1-123 partners with the HR HPV type 16 E6 oncoprotein to affect multiple growth, differentiation, and immune response genes. However, neither the expression of NFX1-123 nor the levels of these genes have been investigated in HPV positive (HPV+) or negative (HPV-) HNSCCs.
The Cancer Genome Atlas Splicing Variants Database and HNSCC cell lines were used to quantify expression of NFX1-123 and cellular genes increased in cervical cancers.
NFX1-123 was increased in HPV+ HNSCCs compared to HPV- HNSCCs. LCE1B, KRT16, SPRR2G, and FBN2 were highly expressed in HNSCCs compared to normal tissues. Notch1 and CCNB1IP1 had greater expression in HPV+ HNSCCs compared to HPV- HNSCCs.
NFX1-123 and a subset of its known targets were increased in HPV+ HNSCCs.
高危型人乳头瘤病毒（HR HPV）几乎可引发所有宫颈癌，而在美国，其还会引发多数头颈部癌症（HNSCC）。NFX1-123 在宫颈癌中过表达，并且与 HR HPV 16 型 E6 致癌蛋白相互作用，影响多个生长、分化和免疫反应基因。然而，在 HPV 阳性（HPV+）或 HPV 阴性（HPV-）HNSCC 中，NFX1-123 的表达及其基因水平均未得到研究。
使用癌症基因组图谱剪接变异体数据库和 HNSCC 细胞系来定量 HPV+ HNSCC 与 HPV- HNSCC 中 NFX1-123 和在宫颈癌中上调的细胞基因的表达。
与 HPV- HNSCC 相比，HPV+ HNSCC 中 NFX1-123 表达上调。与正常组织相比，LCE1B、KRT16、SPRR2G 和 FBN2 在 HNSCC 中表达更高。与 HPV- HNSCC 相比，HPV+ HNSCC 中 Notch1 和 CCNB1IP1 表达更高。
在 HPV+ HNSCC 中，NFX1-123 及其部分已知靶基因表达上调。
