妊娠性幼年型颗粒细胞瘤：病例系列及文献复习。
Juvenile granulosa cell tumor in pregnancy: case series and literature review.
机构信息
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
出版信息
Arch Gynecol Obstet. 2022 May;305(5):1299-1310. doi: 10.1007/s00404-021-06283-5. Epub 2021 Oct 25.
BACKGROUND
Pregnancy complicated with juvenile granulosa cell tumor (JGCT) is very rare; thus, the experience on clinical diagnosis and management is limited.
CASES
Two patients presented with abdominal pain, two were incidentally discovered, one by ultrasonography, and one during a caesarian section. One case received an emergency caesarian section because of tumor rupture at 38th week's gestation, the rest were treated at full term and no abnormalities were detected in the newborns. Three cases received further staging surgery, two of which received postoperative adjuvant chemotherapy. No patient had recurrent disease after a follow-up period spanning from 13 to 57 months.
CONCLUSION
In the absence of emergency, surgery can be delayed without affecting the fetus. More research is needed to determine the value of chemotherapy in FIGO stage I patients.
背景
妊娠合并幼年型颗粒细胞瘤（JGCT）十分罕见，因此，临床诊断和管理经验有限。
病例
两名患者以腹痛就诊，两名患者为偶然发现，一例经超声检查发现，一例在剖宫产术中发现。一例患者因肿瘤破裂于 38 孕周行急诊剖宫产术，其余患者均足月分娩，新生儿未见异常。三例患者进一步行分期手术，其中两例行术后辅助化疗。随访 13-57 个月，所有患者均无疾病复发。
结论
在无紧急情况时，手术可以延迟而不影响胎儿。需要更多的研究来确定化疗在 FIGO Ⅰ期患者中的价值。
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