Department of Biological Sciences, Birla Institute of Technology and Science Pilani, K K Birla Goa campus, Zuarinagar, South Goa, 403726, India.
Department of Zoology, Centurion University of Technology and Management, Bhubaneswar Campus, Khurda, Jatni, 752050, Odisha, India.
Food Environ Virol. 2022 Mar;14(1):10-29. doi: 10.1007/s12560-021-09502-z. Epub 2021 Oct 25.
The Flavivirus genus is divided into four groups: Mosquito-borne flaviviruses, Tick-borne flaviviruses, no-known vector flaviviruses, and Insect specific flaviviruses. Millions of people are affected worldwide every year due to the flaviviral infections. The 5' UTR of the RNA genome plays a critical role in the biology of flaviviruses. To explore any correlation between the topology of the 5' UTR and pathogenesis, a global scale study of the RNA secondary structure of different groups of flaviviruses has been conducted. We found that most of the pathogenic flaviviruses, irrespective of their mode of transmission, tend to form a Y shaped topology in the Stem loop A of the 5' UTR. Some of the current non-pathogenic flaviviruses were also observed to form Y shaped structure. Based on this study, it has been proposed that the flaviviruses having the Y shaped topology in their 5' UTR regions may have the potential to become pathogenic.
蚊媒黄病毒、蜱媒黄病毒、无已知媒介的黄病毒和昆虫特异性黄病毒。每年全世界都有数百万人因黄病毒感染而受到影响。RNA 基因组的 5'UTR 在黄病毒的生物学中起着关键作用。为了探究 5'UTR 的拓扑结构与发病机制之间的任何相关性，对不同组黄病毒的 RNA 二级结构进行了全球范围的研究。我们发现，大多数致病性黄病毒，无论其传播方式如何，在 5'UTR 的茎环 A 中都倾向于形成 Y 形拓扑结构。一些当前的非致病性黄病毒也被观察到形成 Y 形结构。基于这项研究，有人提出，在其 5'UTR 区域具有 Y 形拓扑结构的黄病毒可能具有潜在的致病性。
