Blot W J, Devesa S S, Fraumeni J F
J Natl Cancer Inst. 1987 Mar;78(3):451-4.
Changes in age-specific breast cancer mortality rates among white females in the United States during 1950-80 were shown to be correlated with changes in patterns of childbearing in early adulthood. However, for the most recent 5-year period among women below age 40 years, small declines in breast cancer mortality were observed in the late 1970's, despite a predicted increase following delays in childbearing that began in the 1960's and despite evidence of a rising incidence of the cancer. Although correlation analyses have inherent limitations, the findings raise the possibility that recent changes in the detection and management of breast cancer have contributed to a lowered mortality from this cancer among young American women.
1950年至1980年间，美国白人女性特定年龄乳腺癌死亡率的变化与成年早期生育模式的变化相关。然而，在最近一个5年期间，对于40岁以下的女性，尽管从20世纪60年代开始生育延迟预计会导致乳腺癌死亡率上升，且有证据表明该癌症发病率在上升，但在20世纪70年代后期仍观察到乳腺癌死亡率略有下降。尽管相关性分析存在固有局限性，但这些发现增加了一种可能性，即近期乳腺癌检测和治疗方法的变化导致了美国年轻女性乳腺癌死亡率的降低。
