鼻窦癌的发病率和生存率：1980 年至 2014 年丹麦基于人群的全国性研究。
Incidence and survival in sinonasal carcinoma: a Danish population-based, nationwide study from 1980 to 2014.
机构信息
a Department of Otorhinolaryngology Head and Neck Surgery and Audiology , Rigshospitalet, University of Copenhagen , Copenhagen Oe , Denmark.
b Department of Oncology , Rigshospitalet, University of Copenhagen , Copenhagen Oe , Denmark.
出版信息
Acta Oncol. 2018 Sep;57(9):1152-1158. doi: 10.1080/0284186X.2018.1454603. Epub 2018 Mar 26.
BACKGROUND
Sinonasal cancers are rare and comprise <1% of all malignancies. This study describes incidence and survival in sinonasal carcinomas in Denmark from 1980 to 2014.
METHODS
All patients registered in the Danish Cancer Registry in the period were included. Age-adjusted incidence rate, average annual percentage change, and relative survival were calculated. Age-period-cohort models were constructed.
RESULTS
1,720 patients with sinonasal carcinoma (median age 67 years, 63% males) were identified. There was no significant change in age-adjusted incidence; 0.70 in 1980 to 0.43 per 100,000 in 2014 (p > .05). Relative 5- and 10-year survival were 52% and 40% for men, 58% and 42% for women. An increase in 5-year survival from 1980 to 2014 from 46% to 65% (p < .05) was found. Nasal carcinomas had a significantly better relative survival compared to sinus carcinoma, as did squamous cell carcinomas when compared to neuroendocrine malignancies.
CONCLUSION
In Denmark between 1980 and 2014, the incidence of sinonasal carcinomas has been stable and the relative survival has increased significantly.
背景
鼻窦癌较为罕见，占所有恶性肿瘤的比例不足 1%。本研究描述了丹麦 1980 年至 2014 年期间鼻窦癌的发病率和生存率。
方法
所有在丹麦癌症登记处登记的患者均纳入本研究。计算了年龄调整发病率、平均年百分比变化和相对生存率。构建了年龄-时期-队列模型。
结果
共发现 1720 例鼻窦癌患者（中位年龄 67 岁，男性占 63%）。年龄调整发病率无显著变化，从 1980 年的每 100,000 人 0.70 例降至 2014 年的 0.43 例（p＞.05）。男性患者的 5 年和 10 年相对生存率分别为 52%和 40%，女性患者的生存率分别为 58%和 42%。1980 年至 2014 年，5 年生存率从 46%提高至 65%（p＜.05）。与窦癌相比，鼻腔癌的相对生存率显著提高，与神经内分泌恶性肿瘤相比，鳞状细胞癌的相对生存率也更高。
结论
在丹麦，1980 年至 2014 年期间，鼻窦癌的发病率保持稳定，相对生存率显著提高。
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