Bianchi Francesco Paolo, Tafuri Silvio, Migliore Giovanni, Vimercati Luigi, Martinelli Andrea, Lobifaro Annamaria, Diella Giusy, Stefanizzi Pasquale
Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Bari Policlinico General Hospital, 70124 Bari, Italy.
Vaccines (Basel). 2021 Oct 7;9(10):1143. doi: 10.3390/vaccines9101143.
To combat the COVID-19 pandemic, a mass vaccination campaign was initiated in Italy on 27 December 2020. The vaccine available to immunize Italian healthcare workers (HCWs) was the BNT162b2 mRNA COVID-19 vaccine (Comirnaty). This study evaluated the effectiveness of the vaccine against documented SARS-CoV-2 infection and symptomatic diseases in the medium- to long-term. HCWs at Bari Policlinico University-Hospital (Italy) who completed the vaccination schedule were matched with HCWs who had refused vaccination; the two groups were followed-up for 5 months (January-May 2021). Vaccine effectiveness (VE) against infection was 97.7% (95.4-99.0%) at 14-34 days after the first dose, and 94.8% (87.0-97.8%), 83.0% (65.0-92.0%), and 81.0% (42.0-94.0%) at 14-41, 42-69, and >69 days, respectively, after the second dose. The estimated VE for documented symptomatic disease was 99.2% (96.4-99.8%) at 14-34 days after the first dose and 97.2% (90.3-99.2%), 85.0% (63.0-94.2%), and 88.0% (42.0-97.6%) at 14-41, 42-69, and >69 days, respectively, after the second dose. Efforts to increase vaccination rates should be strengthened, including mandatory vaccination for HCWs and greater incentives to increase vaccine acceptance by the general population.
为抗击新冠疫情，意大利于2020年12月27日启动了大规模疫苗接种运动。用于为意大利医护人员接种的疫苗是BNT162b2 mRNA新冠疫苗（Comirnaty）。本研究评估了该疫苗在中长期预防有记录的新冠病毒感染和症状性疾病方面的有效性。意大利巴里大学综合医院完成疫苗接种程序的医护人员与拒绝接种的医护人员进行了匹配；两组人员随访了5个月（2021年1月至5月）。首剂接种后14至34天，疫苗对感染的有效性（VE）为97.7%（95.4 - 99.0%），第二剂接种后14至41天、42至69天以及>69天的有效性分别为94.8%（87.0 - 97.8%）、83.0%（65.0 - 92.0%）和81.0%（42.0 - 94.0%）。首剂接种后记录的有症状疾病的估计疫苗有效性在14至34天为99.2%（96.4 - 99.8%），第二剂接种后14至41天、42至69天以及>69天分别为97.2%（90.3 - 99.2%）、85.0%（63.0 - 94.2%）和88.0%（42.0 - 97.6%）。应加强提高疫苗接种率的努力，包括对医护人员实行强制接种以及加大激励措施以提高普通民众对疫苗的接受度。
