Institute of Virology Muenster (IVM), Westfaelische Wilhelms-University Muenster, Von-Esmarch-Str. 56, D-48149 Muenster, Germany.
Cells in Motion Interfaculty Centre (CiMIC), Westfaelische Wilhelms-University Muenster, Von-Esmarch-Str. 56, D-48149 Muenster, Germany.
Viruses. 2021 Oct 14;13(10):2068. doi: 10.3390/v13102068.
Respiratory viruses are known to be the most frequent causative mediators of lung infections in humans, bearing significant impact on the host cell signaling machinery due to their host-dependency for efficient replication. Certain cellular functions are actively induced by respiratory viruses for their own benefit. This includes metabolic pathways such as glycolysis, fatty acid synthesis (FAS) and the tricarboxylic acid (TCA) cycle, among others, which are modified during viral infections. Here, we summarize the current knowledge of metabolic pathway modifications mediated by the acute respiratory viruses respiratory syncytial virus (RSV), rhinovirus (RV), influenza virus (IV), parainfluenza virus (PIV), coronavirus (CoV) and adenovirus (AdV), and highlight potential targets and compounds for therapeutic approaches.
呼吸道病毒是已知的导致人类肺部感染的最常见病原体，由于其对有效复制的宿主依赖性，对宿主细胞信号机制产生重大影响。某些细胞功能被呼吸道病毒主动诱导以利于自身。这包括糖酵解、脂肪酸合成（FAS）和三羧酸（TCA）循环等代谢途径，这些途径在病毒感染过程中会发生改变。在这里，我们总结了急性呼吸道病毒（呼吸道合胞病毒（RSV）、鼻病毒（RV）、流感病毒（IV）、副流感病毒（PIV）、冠状病毒（CoV）和腺病毒（AdV）介导的代谢途径改变的最新知识，并强调了治疗方法的潜在靶点和化合物。
